Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractEnteric pathogens of the family Enterobacteriaceae colonize various niches within animals and humans in which they compete with intestinal commensals and are attacked by the host immune system. To survive these hostile environments they possess complex, multilayer regulatory networks that coordinate the control of virulence factors, host-adapted metabolic functions and stress resistance. An important part of these intricate control networks are RNA-based control systems that enable the pathogen to fine-tune its responses. Recent next-generation sequencing approaches revealed a large repertoire of conserved and species-specific riboregulators, including numerous cis- and trans-acting non-coding RNAs, sensory RNA elements (RNA thermometers, riboswitches), regulatory RNA-binding proteins and RNA degrading enzymes which regulate colonization factors, toxins, host defense processes and virulence-relevant physiological and metabolic processes. All of which are important cues for pathogens to sense and respond to fluctuating conditions during the infection. This review covers infection-relevant riboregulators of E. coli, Salmonella, Shigella and Yersinia, highlights their versatile regulatory mechanisms, complex target regulons and functions, and discusses emerging topics and future challenges to fully understand and exploit RNA-based control to combat bacterial infections.
CitationRNA-based mechanisms of virulence control in Enterobacteriaceae. 2016:1-17 RNA Biol
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- RNA Regulators: Formidable Modulators of Yersinia Virulence.
- Authors: Nuss AM, Heroven AK, Dersch P
- Issue date: 2017 Jan
- Small RNA functions in carbon metabolism and virulence of enteric pathogens.
- Authors: Papenfort K, Vogel J
- Issue date: 2014
- Regulating Bacterial Virulence with RNA.
- Authors: Quereda JJ, Cossart P
- Issue date: 2017 Sep 8
- CsrA Participates in a PNPase Autoregulatory Mechanism by Selectively Repressing Translation of pnp Transcripts That Have Been Previously Processed by RNase III and PNPase.
- Authors: Park H, Yakhnin H, Connolly M, Romeo T, Babitzke P
- Issue date: 2015 Dec
- The non-coding RNA world of the bacterial pathogen Listeria monocytogenes.
- Authors: Mellin JR, Cossart P
- Issue date: 2012 Apr