• Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.

      Bihrer, Verena; Waidmann, Oliver; Friedrich-Rust, Mireen; Forestier, Nicole; Susser, Simone; Haupenthal, Jörg; Welker, Martin; Shi, Ying; Peveling-Oberhag, Jan; Polta, Andreas; et al. (2011)
      MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.