• New approaches to control infections: anti-biofilm strategies against gram-negative bacteria.

      Sommer, Roman; Joachim, Ines; Wagner, Stefanie; Titz, Alexander; University of Konstanz, Department of Chemistry and Zukunftskolleg, Universitätsstrasse 10, D-78457 Konstanz. (2013)
      Hospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.