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dc.contributor.authorAlmeida, Luís
dc.contributor.authorLochner, Matthias
dc.contributor.authorBerod, Luciana
dc.contributor.authorSparwasser, Tim
dc.date.accessioned2017-01-26T14:14:40Z
dc.date.available2017-01-26T14:14:40Z
dc.date.issued2016-10
dc.identifier.citationMetabolic pathways in T cell activation and lineage differentiation. 2016, 28 (5):514-524 Semin. Immunol.en
dc.identifier.issn1096-3618
dc.identifier.pmid27825556
dc.identifier.doi10.1016/j.smim.2016.10.009
dc.identifier.urihttp://hdl.handle.net/10033/620750
dc.description.abstractRecent advances in the field of immunometabolism support the concept that fundamental processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses. Key metabolic processes such as glycolysis, fatty acid and mitochondrial metabolism are now recognized as crucial players in T cell activation and differentiation, and their modulation can differentially affect the development of T helper cell lineages. In this review, we describe the diverse metabolic processes that T cells engage during their life cycle from naïve towards effector and memory T cells. We consider in particular how the cellular metabolism may actively support the function of T cells in their different states. Moreover, we discuss how molecular regulators such as mTOR or AMPK link environmental changes to adaptations in the cellular metabolism and elucidate the consequences on T cell differentiation and function.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMetabolic pathways in T cell activation and lineage differentiation.en
dc.typeArticleen
dc.contributor.departmentTwinCore, Centre for experimental and clinical infection research GmbH, Ferodor-Lynen-Str.7,30625 Hannover, Germany.en
dc.identifier.journalSeminars in immunologyen
refterms.dateFOA2018-06-13T04:23:40Z
html.description.abstractRecent advances in the field of immunometabolism support the concept that fundamental processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses. Key metabolic processes such as glycolysis, fatty acid and mitochondrial metabolism are now recognized as crucial players in T cell activation and differentiation, and their modulation can differentially affect the development of T helper cell lineages. In this review, we describe the diverse metabolic processes that T cells engage during their life cycle from naïve towards effector and memory T cells. We consider in particular how the cellular metabolism may actively support the function of T cells in their different states. Moreover, we discuss how molecular regulators such as mTOR or AMPK link environmental changes to adaptations in the cellular metabolism and elucidate the consequences on T cell differentiation and function.


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