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dc.contributor.authorKnobloch, Tobias
dc.contributor.authorDräger, Gerald
dc.contributor.authorCollisi, Wera
dc.contributor.authorSasse, Florenz
dc.contributor.authorKirschning, Andreas
dc.date.accessioned2017-02-06T10:12:17Z
dc.date.available2017-02-06T10:12:17Z
dc.date.issued2012
dc.identifier.citationUnprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations. 2012, 8:861-9 Beilstein J Org Chemen
dc.identifier.issn1860-5397
dc.identifier.pmid23015834
dc.identifier.doi10.3762/bjoc.8.96
dc.identifier.urihttp://hdl.handle.net/10033/620808
dc.description.abstractWe describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleUnprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalBeilstein journal of organic chemistryen
refterms.dateFOA2018-06-13T21:32:56Z
html.description.abstractWe describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity.


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