Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe rise of antibiotic resistance calls for alternative strategies to treat bacterial infections. One attractive strategy is to directly target bacterial virulence factors with anti-virulence drugs. The expression of virulence traits by pathogens is, however, not constitutive but rather induced by the level of stress encountered within the host. Here we use dual RNA sequencing (RNA-seq) to show that intrinsic variability in the level of host resistance greatly affects the pathogen's transcriptome in vivo. Through analysis of the transcriptional profiles of host and pathogen during Staphylococcus aureus infection of two mouse strains, shown to be susceptible (A/J) or resistant (C57BL/6) to the pathogen, we demonstrate that the expression of virulence factors is dependent on the encountered host resistance. We furthermore provide evidence that this dependence strongly influences the efficacy of anti-virulence strategies, highlighting a potential limitation for the implementation of these strategies.
CitationHost-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection. 2017, 8:14268 Nat Commun
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Targeting the host-pathogen interface for treatment of Staphylococcus aureus infection.
- Authors: Park B, Liu GY
- Issue date: 2012 Mar
- HOST-PATHOGEN INTERACTION IN INFECTIONS DUE TO STAPHYLOCOCCUS AUREUS. STAPHYLOCOCCUS AUREUS VIRULENCE FACTORS.
- Authors: Drăgulescu EC, Codiţă I
- Issue date: 2015 Jan-Jun
- Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against <i>Staphylococcus aureus</i>.
- Authors: Gao P, Davies J, Kao RYT
- Issue date: 2017 Sep 5
- A Staphylococcus aureus small RNA is required for bacterial virulence and regulates the expression of an immune-evasion molecule.
- Authors: Chabelskaya S, Gaillot O, Felden B
- Issue date: 2010 Jun 3
- Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.
- Authors: Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE
- Issue date: 2015 Dec