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dc.contributor.authorMinarrieta, Lucía
dc.contributor.authorGhorbani, Peyman
dc.contributor.authorSparwasser, Tim
dc.contributor.authorBerod, Luciana
dc.date.accessioned2017-03-29T09:17:17Z
dc.date.available2017-03-29T09:17:17Z
dc.date.issued2017-02
dc.identifier.citationMetabolites: deciphering the molecular language between DCs and their environment. 2017, 39 (2):177-198 Semin Immunopatholen
dc.identifier.issn1863-2300
dc.identifier.pmid27921148
dc.identifier.doi10.1007/s00281-016-0609-6
dc.identifier.urihttp://hdl.handle.net/10033/620874
dc.description.abstractDendritic cells (DCs) determine the outcome of the immune response based on signals they receive from the environment. Presentation of antigen under various contexts can lead to activation and differentiation of T cells for immunity or dampening of immune responses by establishing tolerance, primarily through the priming of regulatory T cells. Infections, inflammation and normal cellular interactions shape DC responses through direct contact or via cytokine signaling. Although it is widely accepted that DCs sense microbial components through pattern recognition receptors (PRRs), increasing evidence advocates for the existence of a set of signals that can profoundly shape DC function via PRR-independent pathways. This diverse group of host- or commensal-derived metabolites represents a newly appreciated code from which DCs can interpret environmental cues. In this review, we discuss the existing information on the effect of some of the most studied metabolites on DC function, together with the implications this may have in immune-mediated diseases.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMetabolites: deciphering the molecular language between DCs and their environment.en
dc.typeArticleen
dc.contributor.departmentTwincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.en
dc.identifier.journalSeminars in immunopathologyen
refterms.dateFOA2018-02-01T00:00:00Z
html.description.abstractDendritic cells (DCs) determine the outcome of the immune response based on signals they receive from the environment. Presentation of antigen under various contexts can lead to activation and differentiation of T cells for immunity or dampening of immune responses by establishing tolerance, primarily through the priming of regulatory T cells. Infections, inflammation and normal cellular interactions shape DC responses through direct contact or via cytokine signaling. Although it is widely accepted that DCs sense microbial components through pattern recognition receptors (PRRs), increasing evidence advocates for the existence of a set of signals that can profoundly shape DC function via PRR-independent pathways. This diverse group of host- or commensal-derived metabolites represents a newly appreciated code from which DCs can interpret environmental cues. In this review, we discuss the existing information on the effect of some of the most studied metabolites on DC function, together with the implications this may have in immune-mediated diseases.


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