CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis.
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Pils, Marina C
Zur Lage, Susanne
Singh, Anurag K
Falk, Christine S
Hornef, Mathias W
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AbstractMycobacterium avium ssp. paratuberculosis (MAP) is the causative agent of Johne's disease (JD), a chronic inflammatory bowel disease of cattle characterized by intermittent to chronic diarrhea. In addition, MAP has been isolated from Crohn's disease (CD) patients. The impact of MAP on severity of clinical symptoms in JD as well as its role in CD are yet unknown. We have previously shown that MAP is able to colonize inflamed enteric tissue and to exacerbate the inflammatory tissue response (Suwandi et al., 2014). In the present study, we analyzed how repeated MAP administration influences the course of dextran sulfate sodium (DSS)-induced colitis. In comparison to mice exposed to DSS or MAP only, repeated exposure of DSS-treated mice to MAP (DSS/MAP) revealed a significantly enhanced clinical score, reduction of colon length as well as severe CD4(+) T cell infiltration into the colonic lamina propria. Functional analysis identified a critical role of CD4(+) T cells in the MAP-induced disease exacerbation. Additionally, altered immune responses were observed when closely related mycobacteria species such as M. avium ssp. avium and M. avium ssp. hominissuis were administered. These data reveal the specific ability of MAP to aggravate intestinal inflammation and clinical symptoms. Overall, this phenotype is compatible with similar disease promoting capabilites of MAP in JD and CD.
CitationCD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis. 2017, 7:75 Front Cell Infect Microbiol
AffiliationHelmholtz Centre for infection research, Inhoffenstr.7, 38124 Braunschweig, Germany.
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- Experimental colitis is exacerbated by concomitant infection with Mycobacterium avium ssp. paratuberculosis.
- Authors: Suwandi A, Bargen I, Roy B, Pils MC, Krey M, Zur Lage S, Basler T, Rohde M, Falk CS, Hornef MW, Goethe R, Weiss S
- Issue date: 2014 Nov
- Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease.
- Authors: Singh UP, Singh S, Singh R, Karls RK, Quinn FD, Potter ME, Lillard JW Jr
- Issue date: 2007 Aug
- Mycobacterium avium subspecies induce differential expression of pro-inflammatory mediators in a murine macrophage model: evidence for enhanced pathogenicity of Mycobacterium avium subspecies paratuberculosis.
- Authors: Basler T, Geffers R, Weiss S, Valentin-Weigand P, Goethe R
- Issue date: 2008
- Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.
- Authors: Olsen I, Tollefsen S, Aagaard C, Reitan LJ, Bannantine JP, Andersen P, Sollid LM, Lundin KE
- Issue date: 2009 May 22
- Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn's disease and Johne's disease: common neural and immune pathogenicities.
- Authors: Scanu AM, Bull TJ, Cannas S, Sanderson JD, Sechi LA, Dettori G, Zanetti S, Hermon-Taylor J
- Issue date: 2007 Dec