Show simple item record

dc.contributor.authorPoock, Caroline
dc.contributor.authorKalesse, Markus
dc.date.accessioned2017-10-06T09:33:07Z
dc.date.available2017-10-06T09:33:07Z
dc.date.issued2017-09-01
dc.identifier.citationTotal Synthesis of Nannocystin Ax. 2017, 19 (17):4536-4539 Org. Lett.en
dc.identifier.issn1523-7052
dc.identifier.pmid28809579
dc.identifier.doi10.1021/acs.orglett.7b02112
dc.identifier.urihttp://hdl.handle.net/10033/621129
dc.description.abstractThe total synthesis of nannocystin Ax in an overall yield of 11% with 14 steps as the longest linear sequence is reported. Nannocystin Ax is a cytotoxic 21-membered depsipeptide and was isolated from the myxobacterial genus Nannocystis sp. The synthesis uses a vinylogous Horner-Wadsworth-Emmons reaction (HWE) and a vinylogous Mukaiyama aldol reaction (VMAR) as the key steps for the construction of the polyketide fragment. The macrocycle was closed via a macrolactamization reaction using COMU.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleTotal Synthesis of Nannocystin Ax.en
dc.typeArticleen
dc.contributor.departmentHemholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalOrganic lettersen
refterms.dateFOA2018-05-03T00:00:00Z
html.description.abstractThe total synthesis of nannocystin Ax in an overall yield of 11% with 14 steps as the longest linear sequence is reported. Nannocystin Ax is a cytotoxic 21-membered depsipeptide and was isolated from the myxobacterial genus Nannocystis sp. The synthesis uses a vinylogous Horner-Wadsworth-Emmons reaction (HWE) and a vinylogous Mukaiyama aldol reaction (VMAR) as the key steps for the construction of the polyketide fragment. The macrocycle was closed via a macrolactamization reaction using COMU.


Files in this item

Thumbnail
Name:
Total Synthesis of Nannocystin ...
Size:
496.1Kb
Format:
PDF
Description:
submitted manuscript

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/