Total Synthesis of Nannocystin Ax.
dc.contributor.author | Poock, Caroline | |
dc.contributor.author | Kalesse, Markus | |
dc.date.accessioned | 2017-10-06T09:33:07Z | |
dc.date.available | 2017-10-06T09:33:07Z | |
dc.date.issued | 2017-09-01 | |
dc.identifier.citation | Total Synthesis of Nannocystin Ax. 2017, 19 (17):4536-4539 Org. Lett. | en |
dc.identifier.issn | 1523-7052 | |
dc.identifier.pmid | 28809579 | |
dc.identifier.doi | 10.1021/acs.orglett.7b02112 | |
dc.identifier.uri | http://hdl.handle.net/10033/621129 | |
dc.description.abstract | The total synthesis of nannocystin Ax in an overall yield of 11% with 14 steps as the longest linear sequence is reported. Nannocystin Ax is a cytotoxic 21-membered depsipeptide and was isolated from the myxobacterial genus Nannocystis sp. The synthesis uses a vinylogous Horner-Wadsworth-Emmons reaction (HWE) and a vinylogous Mukaiyama aldol reaction (VMAR) as the key steps for the construction of the polyketide fragment. The macrocycle was closed via a macrolactamization reaction using COMU. | |
dc.language.iso | en | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | Total Synthesis of Nannocystin Ax. | en |
dc.type | Article | en |
dc.contributor.department | Hemholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany. | en |
dc.identifier.journal | Organic letters | en |
refterms.dateFOA | 2018-05-03T00:00:00Z | |
html.description.abstract | The total synthesis of nannocystin Ax in an overall yield of 11% with 14 steps as the longest linear sequence is reported. Nannocystin Ax is a cytotoxic 21-membered depsipeptide and was isolated from the myxobacterial genus Nannocystis sp. The synthesis uses a vinylogous Horner-Wadsworth-Emmons reaction (HWE) and a vinylogous Mukaiyama aldol reaction (VMAR) as the key steps for the construction of the polyketide fragment. The macrocycle was closed via a macrolactamization reaction using COMU. |