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dc.contributor.authorRibeiro, Giovanni Monteiro*
dc.contributor.authorMatsumoto, Cristianne Kayoko*
dc.contributor.authorReal, Fernando*
dc.contributor.authorTeixeira, Daniela*
dc.contributor.authorDuarte, Rafael Silva*
dc.contributor.authorMortara, Renato Arruda*
dc.contributor.authorLeão, Sylvia Cardoso*
dc.contributor.authorde Souza Carvalho-Wodarz, Cristiane*
dc.date.accessioned2017-10-24T08:43:03Z
dc.date.available2017-10-24T08:43:03Z
dc.date.issued2017-09-13
dc.identifier.citationIncreased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. 2017, 17 (1):195 BMC Microbiol.en
dc.identifier.issn1471-2180
dc.identifier.pmid28903728
dc.identifier.doi10.1186/s12866-017-1102-7
dc.identifier.urihttp://hdl.handle.net/10033/621143
dc.description.abstractOutbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an epidemic of postsurgical infections and was characterized by increased persistence in vivo. To better understand the successful survival strategies of this microorganism, we evaluated its infectivity and proliferation in macrophages (RAW and BMDM) and alveolar epithelial cells (A549). For that, we assessed the following parameters, for both M. abscessus CRM0019 as well as the reference strain M. abscessus ATCC 19977: internalization, intracellular survival for up 3 days, competence to subvert lysosome fusion and the intracellular survival after cell reinfection.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleIncreased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalBMC microbiologyen
refterms.dateFOA2018-06-12T23:39:29Z
html.description.abstractOutbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an epidemic of postsurgical infections and was characterized by increased persistence in vivo. To better understand the successful survival strategies of this microorganism, we evaluated its infectivity and proliferation in macrophages (RAW and BMDM) and alveolar epithelial cells (A549). For that, we assessed the following parameters, for both M. abscessus CRM0019 as well as the reference strain M. abscessus ATCC 19977: internalization, intracellular survival for up 3 days, competence to subvert lysosome fusion and the intracellular survival after cell reinfection.


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