Increased plasmid copy number is essential for Yersinia T3SS function and virulence.
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Erttmann, Saskia F
Nuss, Aaron M
MetadataShow full item record
AbstractPathogenic bacteria have evolved numerous virulence mechanisms that are essential for establishing infections. The enterobacterium Yersinia uses a type III secretion system (T3SS) encoded by a 70-kilobase, low-copy, IncFII-class virulence plasmid. We report a novel virulence strategy in Y. pseudotuberculosis in which this pathogen up-regulates the plasmid copy number during infection. We found that an increased dose of plasmid-encoded genes is indispensable for virulence and substantially elevates the expression and function of the T3SS. Remarkably, we observed direct, tight coupling between plasmid replication and T3SS function. This regulatory pathway provides a framework for further exploration of the environmental sensing mechanisms of pathogenic bacteria.
CitationIncreased plasmid copy number is essential for Yersinia T3SS function and virulence. 2016, 353 (6298):492-5 Science
AffiliationHelmholtz-Zentrum für Infektionsfoschung GmbH, Inhoffenstr.7, 38124 Braunschweig, Germany.
JournalScience (New York, N.Y.)
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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