Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsMulwa, Lucky S
Praditya, Dimas F
Mohr, Kathrin I
MetadataShow full item record
AbstractTwo new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated from the myxobacteriumLabilithrixluteola(DSM 27648T). Additionally, four metabolites3,4,5and6already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal ¹H-NMR coupling data. The compounds where tested for biological activities; labindoles A (1) and B (2) exhibited significant activity against Hepatitis C Virus, 9H-carbazole (3), 3-chloro-9H-carbazole (4) and 4-hydroxymethyl-quinoline (5) showed antifungal activities. Moreover, compound3had weak to moderate antibacterial activities, while labindoles A (1) and B (2) were devoid of significant antifungal and antibacterial effects.
CitationSix Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. 2018, 23 (3) Molecules
AffiliationHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
JournalMolecules (Basel, Switzerland)
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete <i>Hohenbuehelia grisea</i>.
- Authors: Sandargo B, Thongbai B, Praditya D, Steinmann E, Stadler M, Surup F
- Issue date: 2018 Oct 19
- O-heterocyclic derivatives with antibacterial properties from marine bacterium Bacillus subtilis associated with seaweed, Sargassum myriocystum.
- Authors: Chakraborty K, Thilakan B, Chakraborty RD, Raola VK, Joy M
- Issue date: 2017 Jan
- Hyafurones, hyapyrrolines, and hyapyrones: polyketides from Hyalangium minutum.
- Authors: Okanya PW, Mohr KI, Gerth K, Kessler W, Jansen R, Stadler M, Müller R
- Issue date: 2014 Jun 27
- Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei.
- Authors: Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F
- Issue date: 2016 Feb 26
- Two new polyketides from Nocardiopsis lucentensis DSM 44048.
- Authors: Sun MW, Guo ZX, Lu CH
- Issue date: 2016