Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC mice.
dc.contributor.author | Akeus, Paulina | |
dc.contributor.author | Szeponik, Louis | |
dc.contributor.author | Ahlmanner, Filip | |
dc.contributor.author | Sundström, Patrik | |
dc.contributor.author | Alsén, Samuel | |
dc.contributor.author | Gustavsson, Bengt | |
dc.contributor.author | Sparwasser, Tim | |
dc.contributor.author | Raghavan, Sukanya | |
dc.contributor.author | Quiding-Järbrink, Marianne | |
dc.date.accessioned | 2018-06-18T08:17:07Z | |
dc.date.available | 2018-06-18T08:17:07Z | |
dc.date.issued | 2018-04-18 | |
dc.identifier.issn | 1432-0851 | |
dc.identifier.pmid | 29671006 | |
dc.identifier.doi | 10.1007/s00262-018-2161-9 | |
dc.identifier.uri | http://hdl.handle.net/10033/621400 | |
dc.description.abstract | Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo. Treg depletion also resulted in increased levels of the chemokines CXCL9 and CXCL10 specifically in the tumors. In this study, we investigated the mechanisms for Treg mediated suppression of T-cell migration into intestinal tumors in the APC | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.subject | APCmin/+ | en_US |
dc.subject | CXCR3 | en_US |
dc.subject | Colon cancer | en_US |
dc.subject | Migration | en_US |
dc.subject | Regulatory T cells | en_US |
dc.title | Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC mice. | en_US |
dc.type | Article | en_US |
dc.contributor.department | TWINCORE, Zentrum für experimentelle uns klinische Ifektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany. | en_US |
refterms.dateFOA | 2018-06-18T08:17:08Z | |
dc.source.journaltitle | Cancer immunology, immunotherapy : CII |
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publications of the TwinCore unit Infection immunology [80]
Publications of the Twincore Experimentelle Infektionsforschung