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dc.contributor.authorChalermwatanachai, Thanit
dc.contributor.authorVilchez-Vargas, Ramiro
dc.contributor.authorHoltappels, Gabriele
dc.contributor.authorLacoere, Tim
dc.contributor.authorJáuregui, Ruy
dc.contributor.authorKerckhof, Frederiek-Maarten
dc.contributor.authorPieper, Dietmar H
dc.contributor.authorVan de Wiele, Tom
dc.contributor.authorVaneechoutte, Mario
dc.contributor.authorVan Zele, Thibaut
dc.contributor.authorBachert, Claus
dc.date.accessioned2018-06-18T09:57:34Z
dc.date.available2018-06-18T09:57:34Z
dc.date.issued2018-05-21
dc.identifier.issn2045-2322
dc.identifier.pmid29784985
dc.identifier.doi10.1038/s41598-018-26327-2
dc.identifier.urihttp://hdl.handle.net/10033/621401
dc.description.abstractChronic rhinosinusitis with nasal polyp (CRSwNP) patients are often characterized by asthma comorbidity and a type-2 inflammation of the sinonasal mucosa. The mucosal microbiota has been suggested to be implicated in the persistence of inflammation, but associations have not been well defined. To compare the bacterial communities of healthy subjects with CRSwNP patients, we collected nasal swabs from 17 healthy subjects, 21 CRSwNP patients without asthma (CRSwNP-A), and 20 CRSwNP patients with co-morbid asthma (CRSwNP+A). We analysed the microbiota using high-throughput sequencing of the bacterial 16S rRNA. Bacterial communities were different between the three groups. Haemophilus influenzae was significantly enriched in CRSwNP patients, Propionibacterium acnes in the healthy group; Staphylococcus aureus was abundant in the CRSwNP-A group, even though present in 57% of patients. Escherichia coli was found in high amounts in CRSwNP+A patients. Nasal tissues of CRSwNP+A patients expressed significantly higher concentrations of IgE, SE-IgE, and IL-5 compared to those of CRSwNP-A patients. Co-cultivation demonstrated that P. acnes growth was inhibited by H. influenzae, E. coli and S. aureus. The nasal microbiota of healthy subjects are different from those of CRSwNP-A and CRSwNP+A patients. However, the most abundant species in healthy status could not inhibit those in CRSwNP disease.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleChronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota.en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-06-18T09:57:35Z
dc.source.journaltitleScientific reports


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