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dc.contributor.authorStrunz, Benedikt
dc.contributor.authorHengst, Julia
dc.contributor.authorDeterding, Katja
dc.contributor.authorManns, Michael P
dc.contributor.authorCornberg, Markus
dc.contributor.authorLjunggren, Hans-Gustaf
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorBjörkström, Niklas K
dc.date.accessioned2018-06-25T13:16:54Z
dc.date.available2018-06-25T13:16:54Z
dc.date.issued2018-06-11
dc.identifier.issn2041-1723
dc.identifier.pmid29891939
dc.identifier.doi10.1038/s41467-018-04685-9
dc.identifier.urihttp://hdl.handle.net/10033/621409
dc.description.abstractDiversity is a central requirement for the immune system's capacity to adequately clear a variety of different infections. As such, natural killer (NK) cells represent a highly diverse population of innate lymphocytes important in the early response against viruses. Yet, the extent to which a chronic pathogen affects NK cell diversity is largely unknown. Here we study NK cell functional diversification in chronic hepatitis C virus (HCV) infection. High-dimensional flow cytometer assays combined with stochastic neighbor embedding analysis reveal that chronic HCV infection induces functional imprinting on human NK cells that is largely irreversible and persists long after successful interventional clearance of the virus. Furthermore, HCV infection increases inter-individual, but decreases intra-individual, NK cell diversity. Taken together, our results provide insights into how the history of infections affects human NK cell diversity.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleChronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity.en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-06-25T13:16:54Z
dc.source.journaltitleNature communications


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