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dc.contributor.authorEicke, Dorothee
dc.contributor.authorBaigger, Anja
dc.contributor.authorSchulze, Kai
dc.contributor.authorLatham, Sharissa L
dc.contributor.authorHalloin, Caroline
dc.contributor.authorZweigerdt, Robert
dc.contributor.authorGuzman, Carlos A
dc.contributor.authorBlasczyk, Rainer
dc.contributor.authorFigueiredo, Constança
dc.date.accessioned2018-08-07T09:25:04Z
dc.date.available2018-08-07T09:25:04Z
dc.date.issued2018-07-05
dc.identifier.issn2045-2322
dc.identifier.pmid29977045
dc.identifier.doi10.1038/s41598-018-28459-x
dc.identifier.urihttp://hdl.handle.net/10033/621437
dc.description.abstractMegakaryocytes (MKs) are the precursors of platelets (PLTs) and may be used for PLT production in vivo or in vitro, as well as a source for PLT-derived growth factors. Induced pluripotent stem cells represent an unlimited cell source for the in vitro production of MKs. This study aimed at developing an effective, xeno-free and scalable system to produce high numbers of MKs. In particular, microcarrier beads-assisted stirred bioreactors were evaluated as a means of improving MK yields. This method resulted in the production of 18.7 × 10en_US
dc.language.isoenen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleLarge-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-08-07T09:25:04Z
dc.source.journaltitleScientific reports


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