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dc.contributor.authorLiu, Yun
dc.contributor.authorde Vries, Jan Willem
dc.contributor.authorLiu, Qing
dc.contributor.authorHartman, Alwin M
dc.contributor.authorWieland, Gerhard D
dc.contributor.authorWieczorek, Sebastian
dc.contributor.authorBörner, Hans G
dc.contributor.authorWiehe, Arno
dc.contributor.authorBuhler, Eric
dc.contributor.authorStuart, Marc C A
dc.contributor.authorBrowne, Wesley R
dc.contributor.authorHerrmann, Andreas
dc.contributor.authorHirsch, Anna K H
dc.date.accessioned2018-09-11T11:54:22Z
dc.date.available2018-09-11T11:54:22Z
dc.date.issued2018-01-19
dc.identifier.issn1521-3765
dc.identifier.pmid29194834
dc.identifier.doi10.1002/chem.201705206
dc.identifier.urihttp://hdl.handle.net/10033/621475
dc.description.abstractHydrophobic drug candidates require innovative formulation agents. We designed and synthesized lipid-DNA polymers containing varying numbers of hydrophobic alkyl chains. The hydrophobicity of these amphiphiles is easily tunable by introducing a defined number of alkyl chain-modified nucleotides during standard solid-phase synthesis of DNA using an automated DNA synthesizer. We observed that the resulting self-assembled micelles solubilize the poorly water-soluble drug, meta-tetra-hydroxyphenyl-chlorin (mTHPC) used in photodynamic therapy (PDT) with high loading concentrations and loading capacities. A cell viability study showed that mTHPC-loaded micelles exhibit good biocompatibility without irradiation, and high PDT efficacy upon irradiation. Lipid-DNAs provide a novel class of drug-delivery vehicle, and hybridization of DNA offers a potentially facile route for further functionalization of the drug-delivery system with, for instance, targeting or imaging moieties.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectamphiphilesen_US
dc.subjectdrug deliveryen_US
dc.subjectlipid-DNAen_US
dc.subjectmicellesen_US
dc.subjectphotodynamic therapyen_US
dc.titleLipid-DNAs as Solubilizers of mTHPC.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.en_US
refterms.dateFOA2018-09-11T11:54:23Z
dc.source.journaltitleChemistry (Weinheim an der Bergstrasse, Germany)


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