Lipid-DNAs as Solubilizers of mTHPC.
dc.contributor.author | Liu, Yun | |
dc.contributor.author | de Vries, Jan Willem | |
dc.contributor.author | Liu, Qing | |
dc.contributor.author | Hartman, Alwin M | |
dc.contributor.author | Wieland, Gerhard D | |
dc.contributor.author | Wieczorek, Sebastian | |
dc.contributor.author | Börner, Hans G | |
dc.contributor.author | Wiehe, Arno | |
dc.contributor.author | Buhler, Eric | |
dc.contributor.author | Stuart, Marc C A | |
dc.contributor.author | Browne, Wesley R | |
dc.contributor.author | Herrmann, Andreas | |
dc.contributor.author | Hirsch, Anna K H | |
dc.date.accessioned | 2018-09-11T11:54:22Z | |
dc.date.available | 2018-09-11T11:54:22Z | |
dc.date.issued | 2018-01-19 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.pmid | 29194834 | |
dc.identifier.doi | 10.1002/chem.201705206 | |
dc.identifier.uri | http://hdl.handle.net/10033/621475 | |
dc.description.abstract | Hydrophobic drug candidates require innovative formulation agents. We designed and synthesized lipid-DNA polymers containing varying numbers of hydrophobic alkyl chains. The hydrophobicity of these amphiphiles is easily tunable by introducing a defined number of alkyl chain-modified nucleotides during standard solid-phase synthesis of DNA using an automated DNA synthesizer. We observed that the resulting self-assembled micelles solubilize the poorly water-soluble drug, meta-tetra-hydroxyphenyl-chlorin (mTHPC) used in photodynamic therapy (PDT) with high loading concentrations and loading capacities. A cell viability study showed that mTHPC-loaded micelles exhibit good biocompatibility without irradiation, and high PDT efficacy upon irradiation. Lipid-DNAs provide a novel class of drug-delivery vehicle, and hybridization of DNA offers a potentially facile route for further functionalization of the drug-delivery system with, for instance, targeting or imaging moieties. | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.subject | amphiphiles | en_US |
dc.subject | drug delivery | en_US |
dc.subject | lipid-DNA | en_US |
dc.subject | micelles | en_US |
dc.subject | photodynamic therapy | en_US |
dc.title | Lipid-DNAs as Solubilizers of mTHPC. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany. | en_US |
refterms.dateFOA | 2018-09-11T11:54:23Z | |
dc.source.journaltitle | Chemistry (Weinheim an der Bergstrasse, Germany) |