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dc.contributor.authorBehrendt, Patrick
dc.contributor.authorPerin, Paula
dc.contributor.authorMenzel, Nicolas
dc.contributor.authorBranda, Dominic
dc.contributor.authorPfaender, Stephanie
dc.contributor.authorAlves, Marco P.
dc.contributor.authorThiel, Volker
dc.contributor.authorMeulemann, Philip
dc.contributor.authorColpit, Che C.
dc.contributor.authorSchang, Luis M.
dc.contributor.authorVondran, Florian W.R.
dc.contributor.authorAnggakusuma
dc.contributor.authorManns, Michael P.
dc.contributor.authorSteinmann, Eicke
dc.contributor.authorPietschmann, Thomas
dc.date.accessioned2018-09-17T11:40:52Z
dc.date.available2018-09-17T11:40:52Z
dc.date.issued2017-01-01
dc.identifier.issn1872-9096
dc.identifier.pmid28923507
dc.identifier.doi10.1016/j.antiviral.2017.09.006
dc.identifier.urihttp://hdl.handle.net/10033/621483
dc.description.abstractApproximately 142 million people worldwide are infected with hepatitis C virus (HCV). Although potent direct acting antivirals are available, high costs limit access to treatment. Chronic hepatitis C virus infection remains a major cause of orthotopic liver transplantation. Moreover, re-infection of the graft occurs regularly. Antivirals derived from natural sources might be an alternative and cost-effective option to complement therapy regimens for global control of hepatitis C virus infection. We tested the antiviral properties of a mixture of different Chinese herbs/roots named Zhi Bai Di Huang Wan (ZBDHW) and its individual components on HCV. One of the ZBDHW components, Penta-O-Galloyl-Glucose (PGG), was further analyzed for its mode of action in vitro, its antiviral activity in primary human hepatocytes as well as for its bioavailability and hepatotoxicity in mice. ZBDHW, its component Cortex Moutan and the compound PGG efficiently block entry of HCV of all major genotypes and also of the related flavivirus Zika virus. PGG does not disrupt HCV virion integrity and acts primarily during virus attachment. PGG shows an additive effect when combined with the well characterized HCV inhibitor Daclatasvir. Analysis of bioavailability in mice revealed plasma levels above tissue culture ICen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAntiviralsen_US
dc.subjectBioavailabilityen_US
dc.subjectCortex moutanen_US
dc.subjectEntry inhibitoren_US
dc.subjectHepatitis C virusen_US
dc.subjectNatural compoundsen_US
dc.subjectPenta-O-Galloyl-Glucoseen_US
dc.titlePentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en_US
refterms.dateFOA2018-09-18T00:00:00Z
dc.source.journaltitleAntiviral research


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