Show simple item record

dc.contributor.authorLiu, Yun
dc.contributor.authorBos, I Sophie T
dc.contributor.authorOenema, Tjitske A
dc.contributor.authorMeurs, Herman
dc.contributor.authorMaarsingh, Harm
dc.contributor.authorHirsch, Anna K H
dc.date.accessioned2018-09-19T08:08:09Z
dc.date.available2018-09-19T08:08:09Z
dc.date.issued2018-09-01
dc.identifier.issn1873-3441
dc.identifier.pmid29908939
dc.identifier.doi10.1016/j.ejpb.2018.06.012
dc.identifier.urihttp://hdl.handle.net/10033/621489
dc.description.abstractBudesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize its drug efficacy and reduce adverse effects. In this work, we report the use of lipid-DNAA (UU11mer), featuring two hydrophobic alkyl chains and forming micelles at a comparatively low critical micelle concentration, to render budesonide water-soluble with a high loading capacity (LC). The inhibition of interleukin-8 (IL-8) release shows that the new delivery system retains the inhibitory activity in cell-based assays. In conclusion, this research provides a novel approach to formulate and administer budesonide in a non-invasive manner, which dramatically improves its water-solubility while retaining its bioavailability.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAnti-inflammatoryen_US
dc.subjectBudesonideen_US
dc.subjectDrug deliveryen_US
dc.subjectLipid-DNAen_US
dc.subjectSolubilityen_US
dc.titleDelivery system for budesonide based on lipid-DNA.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.en_US
dc.source.journaltitleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Liu et al.pdf
Embargo:
2019-06-14
Size:
1.022Mb
Format:
PDF
Description:
original manuscript

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States