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dc.contributor.authorPrajeeth, Chittappen K
dc.contributor.authorDittrich-Breiholz, Oliver
dc.contributor.authorTalbot, Steven R
dc.contributor.authorRobert, Philippe A
dc.contributor.authorHuehn, Jochen
dc.contributor.authorStangel, Martin
dc.date.accessioned2018-11-02T11:50:11Z
dc.date.available2018-11-02T11:50:11Z
dc.date.issued2018-01-01
dc.identifier.issn1662-5102
dc.identifier.pmid30364000
dc.identifier.doi10.3389/fncel.2018.00352
dc.identifier.urihttp://hdl.handle.net/10033/621533
dc.description.abstractAutoreactive T cells that infiltrate into the central nervous system (CNS) are believed to have a significant role in mediating the pathology of neuroinflammatory diseases like multiple sclerosis. Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of neuroinflammatory processes. Our previous work demonstrated that effectors secreted by Th1 and Th17 cells have different capacities to influence the phenotype and function of glial cells. We have shown that Th1-derived effectors altered the phenotype and function of both microglia and astrocytes whereas Th17-derived effectors induced direct effects only on astrocytes but not on microglia. Here we investigated if effector molecules associated with IFN-γ producing Th1 cells induced different gene expression profiles in microglia and astrocytes. We performed a microarray analysis of RNA isolated from microglia and astrocytes treated with medium and Th-derived culture supernatants and compared the gene expression data. By using the criteria of 2-fold change and a false discovery rate of 0.01 (correcteden_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectTh1 cellsen_US
dc.subjectastrocytesen_US
dc.subjectcytokinesen_US
dc.subjectinterferon-γen_US
dc.subjectmicrogliaen_US
dc.titleIFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.; BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
refterms.dateFOA2018-11-02T11:50:12Z
dc.source.journaltitleFrontiers in cellular neuroscience


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Attribution-NonCommercial-ShareAlike 3.0 United States
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