Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractCell migration entails a plethora of activities combining the productive exertion of protrusive and contractile forces to allow cells to push and squeeze themselves through cell clumps, interstitial tissues or tissue borders. All these activities require the generation and turnover of actin filaments that arrange into specific, subcellular structures. The most prominent structures mediating the protrusion at the leading edges of cells include lamellipodia and filopodia as well as plasma membrane blebs. Moreover, in cells migrating on planar substratum, mechanical support is being provided by an additional, more proximally located structure termed the lamella. Here, we systematically dissect the literature concerning the mechanisms driving actin filament nucleation and elongation in the best-studied protrusive structure, the lamellipodium. Recent work has shed light on open questions in lamellipodium protrusion, including the relative contributions of nucleation versus elongation to the assembly of both individual filaments and the lamellipodial network as a whole. However, much remains to be learned concerning the specificity and relevance of individual factors, their cooperation and their site-specific functions relative to the importance of global actin monomer and filament homeostasis.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States
- Performance of a population of independent filaments in lamellipodial protrusion.
- Authors: Schaus TE, Borisy GG
- Issue date: 2008 Aug
- Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly.
- Authors: Dimchev G, Steffen A, Kage F, Dimchev V, Pernier J, Carlier MF, Rottner K
- Issue date: 2017 May 15
- Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide.
- Authors: Cramer LP
- Issue date: 1999 Oct 7
- Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes.
- Authors: Steffen A, Faix J, Resch GP, Linkner J, Wehland J, Small JV, Rottner K, Stradal TE
- Issue date: 2006 Jun
- FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
- Authors: Block J, Breitsprecher D, Kühn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K
- Issue date: 2012 Jun 5