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dc.contributor.authorIniyan, Appadurai Muthamil
dc.contributor.authorSudarman, Enge
dc.contributor.authorWink, Joachim
dc.contributor.authorKannan, Rajaretinam Rajesh
dc.contributor.authorVincent, Samuel Gnana Prakash
dc.date.accessioned2018-11-23T13:33:38Z
dc.date.available2018-11-23T13:33:38Z
dc.date.issued2018-10-24
dc.identifier.issn0021-8820
dc.identifier.pmid30356080
dc.identifier.doi10.1038/s41429-018-0115-2
dc.identifier.urihttp://hdl.handle.net/10033/621579
dc.description.abstractBioassay-guided screening of antibacterial compounds from the cultured marine Streptomyces sp. ICN19 provided Ala-geninthiocin (1), along with its known analogs geninthiocin (2) and Val-geninthiocin (3) and the indolocarbazole staurosporine (4). The structure of 1 was determined on the basis of 1D and 2D NMR spectra and ESI-HRMS. The absolute configurations of the amino acid residues were determined by enantioselective GC-MS analysis. Compound 1 exhibited potent activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, Mycobacterium smegmatis, and Micrococcus luteus, as well as cytotoxicity against A549 human lung carcinoma cells with an IC50 value of 6 nMen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleAla-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.source.journaltitleThe Journal of antibiotics


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