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dc.contributor.authorJeron, Andreas
dc.contributor.authorBoehme, Julia D
dc.contributor.authorVolckmar, Julia
dc.contributor.authorGereke, Marcus
dc.contributor.authorYevsa, Tetyana
dc.contributor.authorGeffers, Robert
dc.contributor.authorGuzmán, Carlos A
dc.contributor.authorSchreiber, Jens
dc.contributor.authorStegemann-Koniszewski, Sabine
dc.contributor.authorBruder, Dunja
dc.date.accessioned2019-01-10T14:27:46Z
dc.date.available2019-01-10T14:27:46Z
dc.date.issued2018-09-01
dc.identifier.citationInt J Mol Sci. 2018 Sep 1;19(9). pii: ijms19092602. doi: 10.3390/ijms19092602.en_US
dc.identifier.issn1422-0067
dc.identifier.pmid30200513
dc.identifier.doi10.3390/ijms19092602
dc.identifier.urihttp://hdl.handle.net/10033/621642
dc.description.abstractThe respiratory tract is constantly exposed to the environment and displays a favorable niche for colonizing microorganisms. However, the effects of respiratory bacterial carriage on the immune system and its implications for secondary responses remain largely unclear. We have employed respiratory carriage with Bordetella bronchiseptica as the underlying model to comprehensively address effects on subsequent immune responses. Carriage was associated with the stimulation of Bordetella-specific CD4+, CD8+, and CD4+CD25+Foxp3+ T cell responses, and broad transcriptional activation was observed in CD4+CD25+ T cells. Importantly, transfer of leukocytes from carriers to acutely B. bronchiseptica infected mice, resulted in a significantly increased bacterial burden in the recipient’s upper respiratory tract. In contrast, we found that respiratory B. bronchiseptica carriage resulted in a significant benefit for the host in systemic infection with Listeria monocytogenes. Adaptive responses to vaccination and influenza A virus infection, were unaffected by B. bronchiseptica carriage. These data showed that there were significant immune modulatory processes triggered by B. bronchiseptica carriage, that differentially affect subsequent immune responses. Therefore, our results demonstrated the complexity of immune regulation induced by respiratory bacterial carriage, which can be beneficial or detrimental to the host, depending on the pathogen and the considered compartment.en_US
dc.publisherMDPIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBordetella bronchisepticaen_US
dc.subjectListeria monocytogenesen_US
dc.subjectinfluenza A virusen_US
dc.subjectpolymicrobial interactionsen_US
dc.subjectregulatory T cellsen_US
dc.subjectrespiratory immune regulationen_US
dc.subjectrespiratory microbial carriageen_US
dc.subjectsecondary infectionsen_US
dc.subjectvaccinationen_US
dc.titleRespiratory bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4⁺CD25⁺ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalInternational Journal of Molecular Sciencesen_US
refterms.dateFOA2019-01-10T14:27:47Z
dc.source.journaltitleInternational journal of molecular sciences


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