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dc.contributor.authorKämpfer, Peter
dc.contributor.authorRückert, Christian
dc.contributor.authorBlom, Jochen
dc.contributor.authorGoesmann, Alexander
dc.contributor.authorWink, Joachim
dc.contributor.authorKalinowski, Jörn
dc.contributor.authorGlaeser, Stefanie P
dc.date.accessioned2019-01-11T09:25:57Z
dc.date.available2019-01-11T09:25:57Z
dc.date.issued2018-01-01
dc.identifier.citationInt J Mol Sci. 2018 Sep 1;19(9). pii: ijms19092602. doi: 10.3390/ijms19092602.en_US
dc.identifier.issn1466-5034
dc.identifier.pmid29095140
dc.identifier.doi10.1099/ijsem.0.002418
dc.identifier.urihttp://hdl.handle.net/10033/621644
dc.description.abstracthe respiratory tract is constantly exposed to the environment and displays a favorable niche for colonizing microorganisms. However, the effects of respiratory bacterial carriage on the immune system and its implications for secondary responses remain largely unclear. We have employed respiratory carriage with Bordetella bronchiseptica as the underlying model to comprehensively address effects on subsequent immune responses. Carriage was associated with the stimulation of Bordetella-specific CD4(+), CD8(+), and CD4(+)CD25(+)Foxp3(+) T cell responses, and broad transcriptional activation was observed in CD4(+)CD25(+) T cells. Importantly, transfer of leukocytes from carriers to acutely B. bronchiseptica infected mice, resulted in a significantly increased bacterial burden in the recipient's upper respiratory tract. In contrast, we found that respiratory B. bronchiseptica carriage resulted in a significant benefit for the host in systemic infection with Listeria monocytogenes. Adaptive responses to vaccination and influenza A virus infection, were unaffected by B. bronchiseptica carriage. These data showed that there were significant immune modulatory processes triggered by B. bronchiseptica carriage, that differentially affect subsequent immune responses. Therefore, our results demonstrated the complexity of immune regulation induced by respiratory bacterial carriage, which can be beneficial or detrimental to the host, depending on the pathogen and the considered compartment.en_US
dc.publisherMicrobiology Societyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectStreptomyces canusen_US
dc.subjectStreptomyces ciscaucasicusen_US
dc.subjectgenome sequenceen_US
dc.subjectsynonymyen_US
dc.subjecttaxonomyen_US
dc.titleStreptomyces ciscaucasicus Sveshnikova et al. 1983 is a later subjective synonym of Streptomyces canus Heinemann et al. 1953.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2019-01-11T09:25:58Z
dc.source.journaltitleInternational journal of systematic and evolutionary microbiology


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