Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.
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Authors
Lowinus, TheresaHeidel, Florian H
Bose, Tanima
Nimmagadda, Subbaiah Chary
Schnöder, Tina
Cammann, Clemens
Schmitz, Ingo
Seifert, Ulrike
Fischer, Thomas
Schraven, Burkhart
Bommhardt, Ursula
Issue Date
2019-01-16
Metadata
Show full item recordAbstract
Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated K We analyzed acute lymphoid (Jurkat, CEM) and myeloid (HL-60, Molm-13, OCI-AML-3) leukemia cell lines and patients' acute leukemic blasts after treatment with either drug alone or the combination of cytarabine and memantine. Patch-clamp analysis was performed to evaluate inhibition of K Our study demonstrates that memantine inhibits K Our study underlines inhibition of KPublisher
BMCJournal
Cell Communication and SignalingPubMed ID
30651113Type
ArticleLanguage
enISSN
1478-811Xae974a485f413a2113503eed53cd6c53
10.1186/s12964-018-0317-z
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International