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dc.contributor.authorLowinus, Theresa
dc.contributor.authorHeidel, Florian H
dc.contributor.authorBose, Tanima
dc.contributor.authorNimmagadda, Subbaiah Chary
dc.contributor.authorSchnöder, Tina
dc.contributor.authorCammann, Clemens
dc.contributor.authorSchmitz, Ingo
dc.contributor.authorSeifert, Ulrike
dc.contributor.authorFischer, Thomas
dc.contributor.authorSchraven, Burkhart
dc.contributor.authorBommhardt, Ursula
dc.date.accessioned2019-02-15T12:47:18Z
dc.date.available2019-02-15T12:47:18Z
dc.date.issued2019-01-16
dc.identifier.issn1478-811X
dc.identifier.pmid30651113
dc.identifier.doi10.1186/s12964-018-0317-z
dc.identifier.urihttp://hdl.handle.net/10033/621690
dc.description.abstractTreatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated K We analyzed acute lymphoid (Jurkat, CEM) and myeloid (HL-60, Molm-13, OCI-AML-3) leukemia cell lines and patients' acute leukemic blasts after treatment with either drug alone or the combination of cytarabine and memantine. Patch-clamp analysis was performed to evaluate inhibition of K Our study demonstrates that memantine inhibits K Our study underlines inhibition of Ken_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAcute leukemiaen_US
dc.subjectCell deathen_US
dc.subjectCytarabineen_US
dc.subjectMemantineen_US
dc.subjectSignalingen_US
dc.titleMemantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.en_US
dc.typeArticleen_US
dc.identifier.journalCell Communication and Signalingen_US
refterms.dateFOA2019-02-15T12:47:19Z
dc.source.journaltitleCell communication and signaling : CCS


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