Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.
dc.contributor.author | Lowinus, Theresa | |
dc.contributor.author | Heidel, Florian H | |
dc.contributor.author | Bose, Tanima | |
dc.contributor.author | Nimmagadda, Subbaiah Chary | |
dc.contributor.author | Schnöder, Tina | |
dc.contributor.author | Cammann, Clemens | |
dc.contributor.author | Schmitz, Ingo | |
dc.contributor.author | Seifert, Ulrike | |
dc.contributor.author | Fischer, Thomas | |
dc.contributor.author | Schraven, Burkhart | |
dc.contributor.author | Bommhardt, Ursula | |
dc.date.accessioned | 2019-02-15T12:47:18Z | |
dc.date.available | 2019-02-15T12:47:18Z | |
dc.date.issued | 2019-01-16 | |
dc.identifier.issn | 1478-811X | |
dc.identifier.pmid | 30651113 | |
dc.identifier.doi | 10.1186/s12964-018-0317-z | |
dc.identifier.uri | http://hdl.handle.net/10033/621690 | |
dc.description.abstract | Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated K We analyzed acute lymphoid (Jurkat, CEM) and myeloid (HL-60, Molm-13, OCI-AML-3) leukemia cell lines and patients' acute leukemic blasts after treatment with either drug alone or the combination of cytarabine and memantine. Patch-clamp analysis was performed to evaluate inhibition of K Our study demonstrates that memantine inhibits K Our study underlines inhibition of K | en_US |
dc.language.iso | en | en_US |
dc.publisher | BMC | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Acute leukemia | en_US |
dc.subject | Cell death | en_US |
dc.subject | Cytarabine | en_US |
dc.subject | Memantine | en_US |
dc.subject | Signaling | en_US |
dc.title | Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling. | en_US |
dc.type | Article | en_US |
dc.identifier.journal | Cell Communication and Signaling | en_US |
refterms.dateFOA | 2019-02-15T12:47:19Z | |
dc.source.journaltitle | Cell communication and signaling : CCS |