Hepatitis C Virus.
dc.contributor.author | Pietschmann, Thomas | |
dc.contributor.author | Brown, Richard J P | |
dc.date.accessioned | 2019-02-19T13:32:33Z | |
dc.date.available | 2019-02-19T13:32:33Z | |
dc.date.issued | 2019-01-29 | |
dc.identifier.issn | 1878-4380 | |
dc.identifier.pmid | 30709707 | |
dc.identifier.doi | 10.1016/j.tim.2019.01.001 | |
dc.identifier.uri | http://hdl.handle.net/10033/621698 | |
dc.description.abstract | Hepatitis C virus (HCV) is an enveloped, RNA virus transmitted through blood-to-blood contact. It infects humans only and primarily targets liver cells. HCV evades innate and adaptive immunity and establishes chronic infections in 70% of cases. If untreated, 20% of patients develop liver cirrhosis, and a fraction of these progress to hepatocellular carcinoma. Annually, 400000 patients die globally due to HCV infection. Direct-acting antivirals (DAAs) are licensed and target three viral proteins: the NS3-4A protease needed for processing the viral polyprotein, the NS5A phosphoprotein that regulates RNA replication and virus assembly, and the viral RNA-dependent RNA polymerase (NS5B) that catalyzes genome replication. Combination therapies cure more than 95% of treated patients. Approximately 71 million people are chronically infected and 1.7 million new infections occur annually. Treatment-induced cure does not protect from viral reinfection. A prophylactic vaccine is under development. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | HCV | en_US |
dc.subject | antiviral therapy | en_US |
dc.subject | infection | en_US |
dc.subject | liver disease | en_US |
dc.title | Hepatitis C Virus. | en_US |
dc.type | Article | en_US |
dc.contributor.department | TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany. | en_US |
dc.identifier.journal | Trends in Microbiology | en_US |
dc.source.journaltitle | Trends in microbiology |