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dc.contributor.authorPietschmann, Thomas
dc.contributor.authorBrown, Richard J P
dc.date.accessioned2019-02-19T13:32:33Z
dc.date.available2019-02-19T13:32:33Z
dc.date.issued2019-01-29
dc.identifier.issn1878-4380
dc.identifier.pmid30709707
dc.identifier.doi10.1016/j.tim.2019.01.001
dc.identifier.urihttp://hdl.handle.net/10033/621698
dc.description.abstractHepatitis C virus (HCV) is an enveloped, RNA virus transmitted through blood-to-blood contact. It infects humans only and primarily targets liver cells. HCV evades innate and adaptive immunity and establishes chronic infections in 70% of cases. If untreated, 20% of patients develop liver cirrhosis, and a fraction of these progress to hepatocellular carcinoma. Annually, 400000 patients die globally due to HCV infection. Direct-acting antivirals (DAAs) are licensed and target three viral proteins: the NS3-4A protease needed for processing the viral polyprotein, the NS5A phosphoprotein that regulates RNA replication and virus assembly, and the viral RNA-dependent RNA polymerase (NS5B) that catalyzes genome replication. Combination therapies cure more than 95% of treated patients. Approximately 71 million people are chronically infected and 1.7 million new infections occur annually. Treatment-induced cure does not protect from viral reinfection. A prophylactic vaccine is under development.en_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHCVen_US
dc.subjectantiviral therapyen_US
dc.subjectinfectionen_US
dc.subjectliver diseaseen_US
dc.titleHepatitis C Virus.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalTrends in Microbiologyen_US
dc.source.journaltitleTrends in microbiology


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