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dc.contributor.authorBousis, Spyridon
dc.contributor.authorDiamanti, Eleonora
dc.contributor.authorSlotboom, Dirk J.
dc.contributor.authorHirsch, Anna K. H.
dc.date.accessioned2019-02-20T10:42:06Z
dc.date.available2019-02-20T10:42:06Z
dc.date.issued2019-02
dc.identifier.doi10.1002/adtp.201800066
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.201800066
dc.identifier.urihttp://hdl.handle.net/10033/621700
dc.description.abstractIn an attempt to find new antibiotics, novel ways of interfering with important biological functions should be explored, especially with those which are necessary or even irreplaceable for bacterial survival, growth, and virulence. The purpose of this review is to highlight B‐type vitamin transporters from the energy‐coupling factor (ECF) family, which are not present in humans, as potential antimicrobial targets. In addition, a druggability analysis of an ECF transporter for folic acid and sequence‐conservation studies in seven prominent pathogens revealed new druggable pockets. Evaluation of the presence of de novo biosynthetic routes for the vitamins in question in the seven pathogens confirmed that this target class holds promise for the discovery of antimicrobial drugs with a new mechanism of action, possibly on a broad‐spectrum level.en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/757913en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectantimicrobialsen_US
dc.subjectB-type vitaminsen_US
dc.subjectenergy coupling factor transportersen_US
dc.subjectS-componentsen_US
dc.subjectuptakeen_US
dc.titleEnergy‐Coupling Factor Transporters as Novel Antimicrobial Targetsen_US
dc.typeArticleen_US
dc.identifier.eissn2366-3987
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAdvanced Therapeuticsen_US
refterms.dateFOA2019-02-20T10:42:06Z


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