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dc.contributor.authorSubramaniam, Sivaraman
dc.contributor.authorMüller, Volker S
dc.contributor.authorHering, Nina A
dc.contributor.authorMollenkopf, Hans
dc.contributor.authorBecker, Daniel
dc.contributor.authorHeroven, Ann Kathrin
dc.contributor.authorDersch, Petra
dc.contributor.authorPohlmann, Anne
dc.contributor.authorTedin, Karsten
dc.contributor.authorPorwollik, Steffen
dc.contributor.authorMcClelland, Michael
dc.contributor.authorMeyer, Thomas F
dc.contributor.authorHunke, Sabine
dc.date.accessioned2019-02-26T11:47:35Z
dc.date.available2019-02-26T11:47:35Z
dc.date.issued2019-01-01
dc.identifier.citationPLoS One. 2019 Feb 4;14(2):e0211584. doi: 10.1371/journal.pone.0211584. eCollection 2019.en_US
dc.identifier.issn1932-6203
dc.identifier.pmid30716090
dc.identifier.doi10.1371/journal.pone.0211584
dc.identifier.urihttp://hdl.handle.net/10033/621707
dc.description.abstractThe Cpx-envelope stress system regulates the expression of virulence factors in many Gram-negative pathogens. In Salmonella enterica serovar Typhimurium deletion of the sensor kinase CpxA but not of the response regulator CpxR results in the down regulation of the key regulator for invasion, HilA encoded by the Salmonella pathogenicity island 1 (SPI-1). Here, we provide evidence that cpxA deletion interferes with dephosphorylation of CpxR resulting in increased levels of active CpxR and consequently in misregulation of target genes. 14 potential operons were identified to be under direct control of CpxR. These include the virulence determinants ecotin, the omptin PgtE, and the SPI-2 regulator SsrB. The Tat-system and the PocR regulator that together promote anaerobic respiration of tetrathionate on 1,2-propanediol are also under direct CpxR control. Notably, 1,2-propanediol represses hilA expression. Thus, our work demonstrates for the first time the involvement of the Cpx system in a complex network mediating metabolism and virulence function.en_US
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleContribution of the Cpx envelope stress system to metabolism and virulence regulation in Salmonella enterica serovar Typhimurium.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2019-02-26T11:47:35Z
dc.source.journaltitlePloS one


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