The role of mucus on drug transport and its potential to affect therapeutic outcomes.
dc.contributor.author | Murgia, Xabier | |
dc.contributor.author | Loretz, Brigitta | |
dc.contributor.author | Hartwig, Olga | |
dc.contributor.author | Hittinger, Marius | |
dc.contributor.author | Lehr, Claus-Michael | |
dc.date.accessioned | 2019-05-08T08:02:13Z | |
dc.date.available | 2019-05-08T08:02:13Z | |
dc.date.issued | 2018-01-15 | |
dc.identifier.citation | Adv Drug Deliv Rev. 2018 Jan 15;124:82-97. doi: 10.1016/j.addr.2017.10.009. Epub 2017 Oct 26. | en_US |
dc.identifier.issn | 1872-8294 | |
dc.identifier.pmid | 29106910 | |
dc.identifier.doi | 10.1016/j.addr.2017.10.009 | |
dc.identifier.uri | http://hdl.handle.net/10033/621764 | |
dc.description.abstract | A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell debris. This complex composition yields a tenacious viscoelastic hydrogel that lubricates and protects the exposed epithelia from external threats and enzymatic degradation. The natural protective role of mucus is nowadays acknowledged as a major barrier to be overcome in non-invasive drug delivery. The heterogeneity of mucus components offers a wide range of potential chemical interaction sites for macromolecules, while the mesh-like architecture given to mucus by the intermolecular cross-linking of mucin molecules results in a dense network that physically, and in a size-dependent manner, hinders the diffusion of nanoparticles through mucus. Consequently, drug diffusion, epithelial absorption, drug bioavailability, and ultimately therapeutic outcomes of mucosal drug delivery can be attenuated | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Hydrogel | en_US |
dc.subject | Mucins | en_US |
dc.subject | Mucoadhesion | en_US |
dc.subject | Mucopenetration | en_US |
dc.subject | Mucosal drug delivery | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | PEGylation | en_US |
dc.subject | Rheology | en_US |
dc.title | The role of mucus on drug transport and its potential to affect therapeutic outcomes. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany. | en_US |
dc.identifier.journal | Advanced Drug Delivery Reviews | en_US |
refterms.dateFOA | 2019-05-08T08:02:14Z | |
dc.source.journaltitle | Advanced drug delivery reviews |