Evolutionary model for the unequal segregation of high copy plasmids.
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Issue Date
2019-01-01
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Show full item recordAbstract
Plasmids are extrachromosomal DNA elements of microorganisms encoding beneficial genetic information. They were thought to be equally distributed to daughter cells during cell division. Here we use mathematical modeling to investigate the evolutionary stability of plasmid segregation for high-copy plasmids—plasmids that are present in up to several hundred copies per cell—carrying antibiotic resistance genes. Evolutionary stable strategies (ESS) are determined by numerical analysis of a plasmid-load structured population model. The theory predicts that the evolutionary stable segregation strategy of a cell depends on the plasmid copy number: For low and medium plasmid load, both daughters receive in average an equal share of plasmids, while in case of high plasmid load, one daughter obtains distinctively and systematically more plasmids. These findings are in good agreement with recent experimental results. We discuss the interpretation and practical consequences.Citation
PLoS Comput Biol. 2019 Mar 5;15(3):e1006724. doi: 10.1371/journal.pcbi.1006724 eCollection 2019 Mar.Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.Publisher
PLOSJournal
PLoS computational biologyPubMed ID
30835726Type
ArticleLanguage
enISSN
1553-7358ae974a485f413a2113503eed53cd6c53
10.1371/journal.pcbi.1006724
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