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dc.contributor.authorRisdian, Chandra
dc.contributor.authorMozef, Tjandrawati
dc.contributor.authorWink, Joachim
dc.date.accessioned2019-05-21T12:53:06Z
dc.date.available2019-05-21T12:53:06Z
dc.date.issued2019-05-06
dc.identifier.citationMicroorganisms. 2019 May 6;7(5). pii: microorganisms7050124. doi: 10.3390/microorganisms7050124.en_US
dc.identifier.issn2076-2607
dc.identifier.pmid31064143
dc.identifier.doi10.3390/microorganisms7050124
dc.identifier.urihttp://hdl.handle.net/10033/621792
dc.description.abstractPolyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol, and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists, insects, mollusks, and sponges. Streptomyces is a genus of Gram-positive bacteria that has a filamentous form like fungi. This genus is best known as one of the polyketides producers. Some examples of polyketides produced by Streptomyces are rapamycin, oleandomycin, actinorhodin, daunorubicin, and caprazamycin. Biosynthesis of polyketides involves a group of enzyme activities called polyketide synthases (PKSs). There are three types of PKSs (type I, type II, and type III) in Streptomyces responsible for producing polyketides. This paper focuses on the biosynthesis of polyketides in Streptomyces with three structurally-different types of PKSs.en_US
dc.publisherMDPIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectStreptomycesen_US
dc.subjectpolyketide synthases (PKSs)en_US
dc.subjectpolyketidesen_US
dc.subjectsecondary metaboliteen_US
dc.titleBiosynthesis of Polyketides in Streptomyces.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
dc.identifier.journalMicroorganismsen_US
refterms.dateFOA2019-05-21T12:53:07Z
dc.source.journaltitleMicroorganisms


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