Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy.
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Issue Date
2019-05-30
Metadata
Show full item recordAbstract
Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity. Therefore, a model with heterogeneity was developed and tested using existing experimental data to show the potential effects from the presence of an intratumoral distribution of radiosensitivity on radiation therapy response over a protracted radiation therapy treatment course.Citation
Radiat Oncol. 2019 May 30;14(1):88. doi: 10.1186/s13014-019-1288-y.Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.Publisher
BioMed Central (BMC)Journal
Radiation OncologyPubMed ID
31146751Type
ArticleLanguage
enISSN
1748-717Xae974a485f413a2113503eed53cd6c53
10.1186/s13014-019-1288-y
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