Show simple item record

dc.contributor.authorMascheroni, Pietro
dc.contributor.authorLópez Alfonso, Juan Carlos
dc.contributor.authorKalli, Maria
dc.contributor.authorStylianopoulos, Triantafyllos
dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorHatzikirou, Haralampos
dc.date.accessioned2019-07-11T09:33:40Z
dc.date.available2019-07-11T09:33:40Z
dc.date.issued2019-05-24
dc.identifier.citationCancers (Basel). 2019 May 24;11(5). pii: cancers11050716. doi: 10.3390/cancers11050716.en_US
dc.identifier.issn2072-6694
dc.identifier.pmid31137643
dc.identifier.doi10.3390/cancers11050716
dc.identifier.urihttp://hdl.handle.net/10033/621859
dc.description.abstractTumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo–mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. We discuss how these novel findings increase the current understanding of glioma/microenvironment interactions and can contribute to new strategies for improved therapeutic outcomes. View Full-Texten_US
dc.publisherMPDIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectgliomaen_US
dc.subjectphenotypic transitionsen_US
dc.subjectsolid stressen_US
dc.subjectstress-alleviation therapyen_US
dc.titleOn the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCancersen_US
refterms.dateFOA2019-07-11T09:33:40Z
dc.source.journaltitleCancers


Files in this item

Thumbnail
Name:
Mascheroni et al.pdf
Size:
4.576Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International