Clustered core- and pan-genome content on Rhodobacteraceae chromosomes.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractIn Bacteria, chromosome replication starts at a single origin of replication and proceeds on both replichores. Due to its asymmetric nature, replication influences chromosome structure and gene organization, mutation rate and expression. To date, little is known about the distribution of highly conserved genes over the bacterial chromosome. Here, we used a set of 101 fully-sequenced Rhodobacteraceae representatives to analyze the relationship between conservation of genes within this family and their distance from the origin of replication. Twenty-two of the analyzed species had core genes clustered significantly closer to the origin of replication with representatives of the genus Celeribacter being the most apparent example. Interestingly, there were also eight species with the opposite organization. In particular Rhodobaca barguzinensis and Loktanella vestfoldensis showed a significant increase of core genes with distance from the origin of replication. The uneven distribution of low-conserved regions is in particular pronounced for genomes in which the halves of one replichore differ in their conserved gene content. Phage integration and horizontal gene transfer partially explain the scattered nature of Rhodobacteraceae genomes. Our findings lay the foundation for a better understanding of bacterial genome evolution and the role of replication therein.
CitationGenome Biol Evol. 2019 Jul 3. pii: 5527758. doi: 10.1093/gbe/evz138.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
PublisherOxford University Press
JournalGenome biology and evolution
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Horizontal operon transfer, plasmids, and the evolution of photosynthesis in Rhodobacteraceae.
- Authors: Brinkmann H, Göker M, Koblížek M, Wagner-Döbler I, Petersen J
- Issue date: 2018 Aug
- Clustering of Pan- and Core-genome of Lactobacillus provides Novel Evolutionary Insights for Differentiation.
- Authors: Inglin RC, Meile L, Stevens MJA
- Issue date: 2018 Apr 24
- Chromosome structuring limits genome plasticity in Escherichia coli.
- Authors: Esnault E, Valens M, Espéli O, Boccard F
- Issue date: 2007 Dec
- Periodic Variation of Mutation Rates in Bacterial Genomes Associated with Replication Timing.
- Authors: Dillon MM, Sung W, Lynch M, Cooper VS
- Issue date: 2018 Aug 21
- Dynamics of genome rearrangement in bacterial populations.
- Authors: Darling AE, Miklós I, Ragan MA
- Issue date: 2008 Jul 18