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dc.contributor.authorTang, Benjamin M
dc.contributor.authorShojaei, Maryam
dc.contributor.authorTeoh, Sally
dc.contributor.authorMeyers, Adrienne
dc.contributor.authorHo, John
dc.contributor.authorBall, T Blake
dc.contributor.authorKeynan, Yoav
dc.contributor.authorPisipati, Amarnath
dc.contributor.authorKumar, Aseem
dc.contributor.authorEisen, Damon P
dc.contributor.authorLai, Kevin
dc.contributor.authorGillett, Mark
dc.contributor.authorSantram, Rahul
dc.contributor.authorGeffers, Robert
dc.contributor.authorSchreiber, Jens
dc.contributor.authorMozhui, Khyobeni
dc.contributor.authorHuang, Stephen
dc.contributor.authorParnell, Grant P
dc.contributor.authorNalos, Marek
dc.contributor.authorHolubova, Monika
dc.contributor.authorChew, Tracy
dc.contributor.authorBooth, David
dc.contributor.authorKumar, Anand
dc.contributor.authorMcLean, Anthony
dc.contributor.authorSchughart, Klaus
dc.date.accessioned2019-08-13T09:24:06Z
dc.date.available2019-08-13T09:24:06Z
dc.date.issued2019-07-31
dc.identifier.citationNat Commun. 2019 Jul 31;10(1):3422. doi: 10.1038/s41467-019-11249-y.en_US
dc.identifier.issn2041-1723
dc.identifier.pmid31366921
dc.identifier.doi10.1038/s41467-019-11249-y
dc.identifier.urihttp://hdl.handle.net/10033/621897
dc.description.abstractSevere influenza infection has no effective treatment available. One of the key barriers to developing host-directed therapy is a lack of reliable prognostic factors needed to guide such therapy. Here, we use a network analysis approach to identify host factors associated with severe influenza and fatal outcome. In influenza patients with moderate-to-severe diseases, we uncover a complex landscape of immunological pathways, with the main changes occurring in pathways related to circulating neutrophils. Patients with severe disease display excessive neutrophil extracellular traps formation, neutrophil-inflammation and delayed apoptosis, all of which have been associated with fatal outcome in animal models. Excessive neutrophil activation correlates with worsening oxygenation impairment and predicted fatal outcome (AUROC 0.817-0.898). These findings provide new evidence that neutrophil-dominated host response is associated with poor outcomes. Measuring neutrophil-related changes may improve risk stratification and patient selection, a critical first step in developing host-directed immune therapy.en_US
dc.language.isoenen_US
dc.publisherSpringer-Natureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleNeutrophils-related host factors associated with severe disease and fatality in patients with influenza infection.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalNature Communicationsen_US
refterms.dateFOA2019-08-13T09:24:07Z
dc.source.journaltitleNature communications


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