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dc.contributor.authorKordes, Adrian
dc.contributor.authorPreusse, Matthias
dc.contributor.authorWillger, Sven D
dc.contributor.authorBraubach, Peter
dc.contributor.authorJonigk, Danny
dc.contributor.authorHaverich, Axel
dc.contributor.authorWarnecke, Gregor
dc.contributor.authorHäussler, Susanne
dc.date.accessioned2019-08-13T10:54:54Z
dc.date.available2019-08-13T10:54:54Z
dc.date.issued2019-07-30
dc.identifier.citationNat Commun. 2019 Jul 30;10(1):3397. doi: 10.1038/s41467-019-11414-3.en_US
dc.identifier.issn2041-1723
dc.identifier.pmid31363089
dc.identifier.doi10.1038/s41467-019-11414-3
dc.identifier.urihttp://hdl.handle.net/10033/621898
dc.description.abstractPrevious studies have demonstrated substantial genetic diversification of Pseudomonas aeruginosa across sub-compartments in cystic fibrosis (CF) lungs. Here, we isolate P. aeruginosa from five different sampling areas in the upper and lower airways of an explanted CF lung, analyze ex vivo transcriptional profiles by RNA-seq, and use colony re-sequencing and deep population sequencing to determine the genetic diversity within and across the various sub-compartments. We find that, despite genetic variation, the ex vivo transcriptional profiles of P. aeruginosa populations inhabiting different regions of the CF lung are similar. Although we cannot estimate the extent to which the transcriptional response recorded here actually reflects the in vivo transcriptomes, our results indicate that there may be a common in vivo transcriptional profile in the CF lung environment.en_US
dc.language.isoenen_US
dc.publisherSpringer-Natureen_US
dc.relation'info:eu-repo/grantAgreement/EC/H2020/724290en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleGenetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalNature Communicationsen_US
refterms.dateFOA2019-08-13T10:54:54Z
dc.source.journaltitleNature communications


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