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dc.contributor.authorThänert, Robert
dc.contributor.authorItzek, Andreas
dc.contributor.authorHoßmann, Jörn
dc.contributor.authorHamisch, Domenica
dc.contributor.authorMadsen, Martin Bruun
dc.contributor.authorHyldegaard, Ole
dc.contributor.authorSkrede, Steinar
dc.contributor.authorBruun, Trond
dc.contributor.authorNorrby-Teglund, Anna
dc.contributor.authorMedina, Eva
dc.contributor.authorPieper, Dietmar H.
dc.date.accessioned2019-09-11T10:54:51Z
dc.date.available2019-09-11T10:54:51Z
dc.date.issued2019-08-26
dc.identifier.citationNat Commun. 2019 Aug 26;10(1):3846. doi: 10.1038/s41467-019-11722-8.en_US
dc.identifier.issn2041-1723
dc.identifier.pmid31451691
dc.identifier.doi10.1038/s41467-019-11722-8
dc.identifier.urihttp://hdl.handle.net/10033/621933
dc.description.abstractNecrotizing soft tissue infections (NSTIs) are devastating infections caused by either a single pathogen, predominantly Streptococcus pyogenes, or by multiple bacterial species. A better understanding of the pathogenic mechanisms underlying these different NSTI types could facilitate faster diagnostic and more effective therapeutic strategies. Here, we integrate microbial community profiling with host and pathogen(s) transcriptional analysis in patient biopsies to dissect the pathophysiology of streptococcal and polymicrobial NSTIs. We observe that the pathogenicity of polymicrobial communities is mediated by synergistic interactions between community members, fueling a cycle of bacterial colonization and inflammatory tissue destruction. In S. pyogenes NSTIs, expression of specialized virulence factors underlies infection pathophysiology. Furthermore, we identify a strong interferon-related response specific to S. pyogenes NSTIs that could be exploited as a potential diagnostic biomarker. Our study provides insights into the pathophysiology of mono- and polymicrobial NSTIs and highlights the potential of host-derived signatures for microbial diagnosis of NSTIs.en_US
dc.language.isoenen_US
dc.publisherNatureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectGeneral Biochemistry, Genetics and Molecular Biologyen_US
dc.subjectGeneral Physics and Astronomyen_US
dc.subjectGeneral Chemistryen_US
dc.titleMolecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infectionsen_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalNature communicationsen_US
dc.source.volume10
dc.source.issue1
refterms.dateFOA2019-09-11T10:54:52Z


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