Age-related susceptibility to Streptococcus pyogenes infection in mice: underlying immune dysfunction and strategy to enhance immunity.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractEpidemiological studies have shown that the elderly are at higher risk of severe Streptococcus pyogenes infections. In this study, we used a mouse model that displays the age-related loss of resistance to S. pyogenes infection seen in humans to investigate the impaired immune mechanism underlying the age-associated susceptibility to this pathogen. Young (2-3 months old) and aged (>20 months old) BALB/c mice were subcutaneously or intravenously inoculated with S. pyogenes and their capacity to control infection was compared. Aged mice showed faster progression of disease, earlier morbidity, and increased mortality when compared with young animals. Since macrophages are critical for host defence against S. pyogenes, we investigated whether susceptibility of aged mice may be due to an age-associated decline in the functionality of these cells. Our results showed that macrophages from aged mice were as capable as those from young animals to uptake and kill S. pyogenes, but the number of resident tissue macrophages was significantly reduced in the aged host. Treatment of aged mice with macrophage colony-stimulating factor (M-CSF) significantly increased the number of resident macrophages and improved their response to infection. Our results indicate that treatment with M-CSF can restore, at least in part, the mechanisms affected by immunosenescence and enhance the natural resistance of aged mice to infection with S. pyogenes.
CitationAge-related susceptibility to Streptococcus pyogenes infection in mice: underlying immune dysfunction and strategy to enhance immunity. 2010, 220 (5):521-9 J. Pathol.
AffiliationInfection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany.
JournalThe Journal of pathology
The following license files are associated with this item:
- Immunosenescence and its potential modulation: lessons from mouse models.
- Authors: Boldizsar F, Mikecz K, Glant TT
- Issue date: 2010 May
- Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion.
- Authors: Medina E, Goldmann O, Toppel AW, Chhatwal GS
- Issue date: 2003 Feb 15
- Immune mechanisms underlying host susceptibility to infection with group A streptococci.
- Authors: Goldmann O, Chhatwal GS, Medina E
- Issue date: 2003 Mar 1
- Role of macrophages in host resistance to group A streptococci.
- Authors: Goldmann O, Rohde M, Chhatwal GS, Medina E
- Issue date: 2004 May
- The role of the MHC on resistance to group a streptococci in mice.
- Authors: Goldmann O, Lengeling A, Böse J, Bloecker H, Geffers R, Chhatwal GS, Medina E
- Issue date: 2005 Sep 15