2.50
Hdl Handle:
http://hdl.handle.net/10033/14549
Title:
The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity.
Authors:
Bredenbruch, Florian; Geffers, Robert; Nimtz, Manfred; Buer, Jan; Häussler, Susanne
Abstract:
Virulence factor production and the development of biofilms in Pseudomonas aeruginosa have been shown to be regulated by two hierarchically organized quorum-sensing systems activated by two types of small acyl-homoserine lactone signal molecules. Recently, a third type of bacterial signal molecule, the Pseudomonas quinolone signal (PQS), has been identified, which positively regulates a subset of genes dependent on the quorum-sensing systems. However, the molecular mechanism underlying PQS signalling has remained poorly understood. In this study the global transcriptional profile of P. aeruginosa in response to PQS revealed a marked upregulation of genes belonging to the tightly interdependent functional groups of the iron acquisition and the oxidative stress response. Remarkably, most of the differentially regulated genes, as well as the induction of rhlR, could be traced back to an iron-chelating effect of PQS. Our results amount to the elucidation of how PQS affects P. aeruginosa and have important implications for the understanding of the complex regulatory circuits involved in P. aeruginosa gene regulation.
Citation:
Environ. Microbiol. 2006, 8(8):1318-29
Issue Date:
1-Aug-2006
URI:
http://hdl.handle.net/10033/14549
DOI:
10.1111/j.1462-2920.2006.01025.x
PubMed ID:
16872396
Type:
Article
Language:
en
ISSN:
1462-2912
Appears in Collections:
publications of the research group chronic pseudomonas infections (CPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorBredenbruch, Florian-
dc.contributor.authorGeffers, Robert-
dc.contributor.authorNimtz, Manfred-
dc.contributor.authorBuer, Jan-
dc.contributor.authorHäussler, Susanne-
dc.date.accessioned2007-11-13T12:28:37Z-
dc.date.available2007-11-13T12:28:37Z-
dc.date.issued2006-08-01-
dc.identifier.citationEnviron. Microbiol. 2006, 8(8):1318-29en
dc.identifier.issn1462-2912-
dc.identifier.pmid16872396-
dc.identifier.doi10.1111/j.1462-2920.2006.01025.x-
dc.identifier.urihttp://hdl.handle.net/10033/14549-
dc.description.abstractVirulence factor production and the development of biofilms in Pseudomonas aeruginosa have been shown to be regulated by two hierarchically organized quorum-sensing systems activated by two types of small acyl-homoserine lactone signal molecules. Recently, a third type of bacterial signal molecule, the Pseudomonas quinolone signal (PQS), has been identified, which positively regulates a subset of genes dependent on the quorum-sensing systems. However, the molecular mechanism underlying PQS signalling has remained poorly understood. In this study the global transcriptional profile of P. aeruginosa in response to PQS revealed a marked upregulation of genes belonging to the tightly interdependent functional groups of the iron acquisition and the oxidative stress response. Remarkably, most of the differentially regulated genes, as well as the induction of rhlR, could be traced back to an iron-chelating effect of PQS. Our results amount to the elucidation of how PQS affects P. aeruginosa and have important implications for the understanding of the complex regulatory circuits involved in P. aeruginosa gene regulation.en
dc.format.extent706256 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleThe Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity.en
dc.typeArticleen
dc.format.digYES-

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