Total synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block.

2.50
Hdl Handle:
http://hdl.handle.net/10033/15718
Title:
Total synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block.
Authors:
Galeyeva, Yana; Helbig, Sarah; Morr, Michael; Sasse, Florenz; Nimtz, Manfred; Laschat, Sabine; Baro, Angelika
Abstract:
Unnatural (-)-pectinatone ((-)-3) was prepared in five steps starting from the highly methyl-branched wax ester 4, employing bromination of the ester enolate and subsequent base-induced elimination to the enoate 6 as the key step. Both (-)-3 and the amides 8b and 8c, which were isolated as by-products in the reaction sequence, displayed antimicrobial activity and cytotoxicity.
Affiliation:
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart.
Citation:
Total synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block. 2006, 3 (8):935-41 Chem. Biodivers.
Journal:
Chemistry & biodiversity
Issue Date:
Aug-2006
URI:
http://hdl.handle.net/10033/15718
DOI:
10.1002/cbdv.200690096
PubMed ID:
17193325
Type:
Article
Language:
en
ISSN:
1612-1880
Appears in Collections:
Publications from Division of Molekulare Struktur Biologie (MOSB)

Full metadata record

DC FieldValue Language
dc.contributor.authorGaleyeva, Yana-
dc.contributor.authorHelbig, Sarah-
dc.contributor.authorMorr, Michael-
dc.contributor.authorSasse, Florenz-
dc.contributor.authorNimtz, Manfred-
dc.contributor.authorLaschat, Sabine-
dc.contributor.authorBaro, Angelika-
dc.date.accessioned2008-01-04T14:51:08Z-
dc.date.available2008-01-04T14:51:08Z-
dc.date.issued2006-08-
dc.identifier.citationTotal synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block. 2006, 3 (8):935-41 Chem. Biodivers.en
dc.identifier.issn1612-1880-
dc.identifier.pmid17193325-
dc.identifier.doi10.1002/cbdv.200690096-
dc.identifier.urihttp://hdl.handle.net/10033/15718-
dc.description.abstractUnnatural (-)-pectinatone ((-)-3) was prepared in five steps starting from the highly methyl-branched wax ester 4, employing bromination of the ester enolate and subsequent base-induced elimination to the enoate 6 as the key step. Both (-)-3 and the amides 8b and 8c, which were isolated as by-products in the reaction sequence, displayed antimicrobial activity and cytotoxicity.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshBiological Productsen
dc.subject.meshCell Lineen
dc.subject.meshEscherichia colien
dc.subject.meshEstersen
dc.subject.meshMiceen
dc.subject.meshMicrococcus luteusen
dc.subject.meshMolecular Structureen
dc.subject.meshPyronesen
dc.subject.meshStaphylococcus aureusen
dc.subject.meshWaxesen
dc.titleTotal synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block.en
dc.typeArticleen
dc.contributor.departmentInstitut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart.en
dc.identifier.journalChemistry & biodiversityen

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