2.50
Hdl Handle:
http://hdl.handle.net/10033/17232
Title:
Screening of photochemically grafted polymer films for compatibility with osteogenic precursor cells.
Authors:
Adden, Nina; Hoffmann, Andrea; Gross, Gerhard; Windhagen, Henning; Thorey, Fritz; Menzel, Henning
Abstract:
Surfaces of biomaterials often do not have the ideal properties for direct application in vivo. Although titanium and its alloys show a good biocompatibility, in some applications there is still need to improve the osteoblast adhesion to titanium implants. A polymeric surface coating is an ideal solution because the polymer can be adjusted to the needs of the application and can be bound to the surface by the photochemical grafting method. Therefore, 22 different polymers were tested for their compatibility using a murine mesenchymal progenitor cell line and three polymers were identified for which more elaborate investigations are reasonable. It was investigated whether or not the results of the cell culture test can be correlated with, e.g., the wetting properties. Indeed it was found that a contact angle above approx. 45 degrees was necessary for good cell adhesion and proliferation. However, otherwise no clear correlation between the contact angle hysteresis or the functionalities of the polymers and the cell growth was observed.
Affiliation:
Institut für Technische Chemie, Abt. TC Makromolekularer Stoffe, Technische Universität Braunschweig, Hans-Sommer-Strasse 10, D-38106 Braunschweig, Germany.
Citation:
Screening of photochemically grafted polymer films for compatibility with osteogenic precursor cells. 2007, 18 (3):303-16notJ Biomater Sci Polym Ed
Journal:
Journal of biomaterials science. Polymer edition
Issue Date:
2007
URI:
http://hdl.handle.net/10033/17232
PubMed ID:
17471767
Type:
Article
Language:
en
ISSN:
0920-5063
Appears in Collections:
Publications of Dept. Gene Regulation and Differentiation (RDIF)

Full metadata record

DC FieldValue Language
dc.contributor.authorAdden, Nina-
dc.contributor.authorHoffmann, Andrea-
dc.contributor.authorGross, Gerhard-
dc.contributor.authorWindhagen, Henning-
dc.contributor.authorThorey, Fritz-
dc.contributor.authorMenzel, Henning-
dc.date.accessioned2008-01-31T14:30:10Z-
dc.date.available2008-01-31T14:30:10Z-
dc.date.issued2007-
dc.identifier.citationScreening of photochemically grafted polymer films for compatibility with osteogenic precursor cells. 2007, 18 (3):303-16notJ Biomater Sci Polym Eden
dc.identifier.issn0920-5063-
dc.identifier.pmid17471767-
dc.identifier.urihttp://hdl.handle.net/10033/17232-
dc.description.abstractSurfaces of biomaterials often do not have the ideal properties for direct application in vivo. Although titanium and its alloys show a good biocompatibility, in some applications there is still need to improve the osteoblast adhesion to titanium implants. A polymeric surface coating is an ideal solution because the polymer can be adjusted to the needs of the application and can be bound to the surface by the photochemical grafting method. Therefore, 22 different polymers were tested for their compatibility using a murine mesenchymal progenitor cell line and three polymers were identified for which more elaborate investigations are reasonable. It was investigated whether or not the results of the cell culture test can be correlated with, e.g., the wetting properties. Indeed it was found that a contact angle above approx. 45 degrees was necessary for good cell adhesion and proliferation. However, otherwise no clear correlation between the contact angle hysteresis or the functionalities of the polymers and the cell growth was observed.en
dc.language.isoenen
dc.subject.meshAcrylamidesen
dc.subject.meshAlloysen
dc.subject.meshAnimalsen
dc.subject.meshBiocompatible Materialsen
dc.subject.meshBiopolymersen
dc.subject.meshBone and Bonesen
dc.subject.meshCell Adhesionen
dc.subject.meshHumansen
dc.subject.meshMolecular Conformationen
dc.subject.meshOsteogenesisen
dc.subject.meshPhotochemistryen
dc.subject.meshPolymethacrylic Acidsen
dc.subject.meshStyrenesen
dc.subject.meshSurface Propertiesen
dc.subject.meshTitaniumen
dc.titleScreening of photochemically grafted polymer films for compatibility with osteogenic precursor cells.en
dc.typeArticleen
dc.contributor.departmentInstitut für Technische Chemie, Abt. TC Makromolekularer Stoffe, Technische Universität Braunschweig, Hans-Sommer-Strasse 10, D-38106 Braunschweig, Germany.en
dc.identifier.journalJournal of biomaterials science. Polymer editionen

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