Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.
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Authors
Chhatwal, PatrickBankwitz, Dorothea
Gentzsch, Juliane
Frentzen, Anne
Schult, Philipp
Lohmann, Volker
Pietschmann, Thomas
Issue Date
2012
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Show full item recordAbstract
Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.Citation
Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONEAffiliation
Department of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.Journal
PloS onePubMed ID
22558311Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0036029
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