2.50
Hdl Handle:
http://hdl.handle.net/10033/255243
Title:
Vaccines: from empirical development to rational design.
Authors:
Rueckert, Christine; Guzmán, Carlos A
Abstract:
Infectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development.
Affiliation:
Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Citation:
Vaccines: from empirical development to rational design. 2012, 8 (11):e1003001 PLoS Pathog.
Journal:
PLoS pathogens
Issue Date:
Nov-2012
URI:
http://hdl.handle.net/10033/255243
DOI:
10.1371/journal.ppat.1003001
PubMed ID:
23144616
Type:
Article
Language:
en
ISSN:
1553-7374
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorRueckert, Christineen_GB
dc.contributor.authorGuzmán, Carlos Aen_GB
dc.date.accessioned2012-12-11T15:38:47Z-
dc.date.available2012-12-11T15:38:47Z-
dc.date.issued2012-11-
dc.identifier.citationVaccines: from empirical development to rational design. 2012, 8 (11):e1003001 PLoS Pathog.en_GB
dc.identifier.issn1553-7374-
dc.identifier.pmid23144616-
dc.identifier.doi10.1371/journal.ppat.1003001-
dc.identifier.urihttp://hdl.handle.net/10033/255243-
dc.description.abstractInfectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PLoS pathogensen_GB
dc.titleVaccines: from empirical development to rational design.en
dc.typeArticleen
dc.contributor.departmentDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en_GB
dc.identifier.journalPLoS pathogensen_GB

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