2.50
Hdl Handle:
http://hdl.handle.net/10033/269743
Title:
Thermosensing to adjust bacterial virulence in a fluctuating environment.
Authors:
Steinmann, Rebekka; Dersch, Petra
Abstract:
The lifecycle of most microbial pathogens can be divided into two states: existence outside and inside their hosts. The sudden temperature upshift experienced upon entry from environmental or vector reservoirs into a warm-blooded host is one of the most crucial signals informing the pathogens to adjust virulence gene expression and their host-stress survival program. This article reviews the plethora of sophisticated strategies that bacteria have evolved to sense temperature, and outlines the molecular signal transduction mechanisms used to modulate synthesis of crucial virulence determinants. The molecular details of thermal control through conformational changes of DNA, RNA and proteins are summarized, complex and diverse thermosensing principles are introduced and their potential as drug targets or synthetic tools are discussed.
Affiliation:
Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Citation:
Thermosensing to adjust bacterial virulence in a fluctuating environment. 2013, 8:85-105 Future Microbiol
Journal:
Future microbiology
Issue Date:
Jan-2013
URI:
http://hdl.handle.net/10033/269743
DOI:
10.2217/fmb.12.129
PubMed ID:
23252495
Type:
Article
Language:
en
ISSN:
1746-0921
Appears in Collections:
publications of the department of molecular Infectionbiology (MIBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorSteinmann, Rebekkaen_GB
dc.contributor.authorDersch, Petraen_GB
dc.date.accessioned2013-02-19T13:41:17Z-
dc.date.available2013-02-19T13:41:17Z-
dc.date.issued2013-01-
dc.identifier.citationThermosensing to adjust bacterial virulence in a fluctuating environment. 2013, 8:85-105 Future Microbiolen_GB
dc.identifier.issn1746-0921-
dc.identifier.pmid23252495-
dc.identifier.doi10.2217/fmb.12.129-
dc.identifier.urihttp://hdl.handle.net/10033/269743-
dc.description.abstractThe lifecycle of most microbial pathogens can be divided into two states: existence outside and inside their hosts. The sudden temperature upshift experienced upon entry from environmental or vector reservoirs into a warm-blooded host is one of the most crucial signals informing the pathogens to adjust virulence gene expression and their host-stress survival program. This article reviews the plethora of sophisticated strategies that bacteria have evolved to sense temperature, and outlines the molecular signal transduction mechanisms used to modulate synthesis of crucial virulence determinants. The molecular details of thermal control through conformational changes of DNA, RNA and proteins are summarized, complex and diverse thermosensing principles are introduced and their potential as drug targets or synthetic tools are discussed.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Future microbiologyen_GB
dc.titleThermosensing to adjust bacterial virulence in a fluctuating environment.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en_GB
dc.identifier.journalFuture microbiologyen_GB

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