2.50
Hdl Handle:
http://hdl.handle.net/10033/281353
Title:
Cellular immune reactions in the lung.
Authors:
Hasenberg, Mike; Stegemann-Koniszewski, Sabine; Gunzer, Matthias
Abstract:
The lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, complex structures and mechanisms have evolved to recognize and fend off environmental dangers while at the same time allowing efficient gas exchange. Here we review our current knowledge regarding cellular mechanisms of the immune system in context with the highly specialized anatomical features of the airways and especially the alveolar compartment. The focus is on fungal and viral infections, merging anatomical aspects well known to pulmonologists with fundamental immunological concepts. We discuss the specialized morphological constraints of immune cells compressed under a continuous layer of the surfactant lining within alveoli as well as the importance of functional polarization of respiratory tract epithelia. Furthermore, we summarize the different types of innate and adaptive immune cells and their relative contribution to lung homeostasis with respect to localization. Finally, we provide a list of currently unresolved questions with high relevance for the field that might serve as food for thought regarding future research directions.
Affiliation:
Institute of Experimental Immunology and Imaging, University of Duisburg/Essen, University Hospital, Essen, Germany.
Citation:
Cellular immune reactions in the lung. 2013, 251 (1):189-214 Immunol. Rev.
Journal:
Immunological reviews
Issue Date:
Jan-2013
URI:
http://hdl.handle.net/10033/281353
DOI:
10.1111/imr.12020
PubMed ID:
23278750
Type:
Article
Language:
en
ISSN:
1600-065X
Appears in Collections:
publications of the department Regulation of infection

Full metadata record

DC FieldValue Language
dc.contributor.authorHasenberg, Mikeen_GB
dc.contributor.authorStegemann-Koniszewski, Sabineen_GB
dc.contributor.authorGunzer, Matthiasen_GB
dc.date.accessioned2013-04-15T14:10:55Z-
dc.date.available2013-04-15T14:10:55Z-
dc.date.issued2013-01-
dc.identifier.citationCellular immune reactions in the lung. 2013, 251 (1):189-214 Immunol. Rev.en_GB
dc.identifier.issn1600-065X-
dc.identifier.pmid23278750-
dc.identifier.doi10.1111/imr.12020-
dc.identifier.urihttp://hdl.handle.net/10033/281353-
dc.description.abstractThe lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, complex structures and mechanisms have evolved to recognize and fend off environmental dangers while at the same time allowing efficient gas exchange. Here we review our current knowledge regarding cellular mechanisms of the immune system in context with the highly specialized anatomical features of the airways and especially the alveolar compartment. The focus is on fungal and viral infections, merging anatomical aspects well known to pulmonologists with fundamental immunological concepts. We discuss the specialized morphological constraints of immune cells compressed under a continuous layer of the surfactant lining within alveoli as well as the importance of functional polarization of respiratory tract epithelia. Furthermore, we summarize the different types of innate and adaptive immune cells and their relative contribution to lung homeostasis with respect to localization. Finally, we provide a list of currently unresolved questions with high relevance for the field that might serve as food for thought regarding future research directions.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Immunological reviewsen_GB
dc.titleCellular immune reactions in the lung.en
dc.typeArticleen
dc.contributor.departmentInstitute of Experimental Immunology and Imaging, University of Duisburg/Essen, University Hospital, Essen, Germany.en_GB
dc.identifier.journalImmunological reviewsen_GB
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