Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.
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Issue Date
2008-06
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Show full item recordAbstract
Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.Citation
Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. 2008, 67 (6):594-602 Scand. J. Immunol.Affiliation
Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.PubMed ID
18433404Type
ArticleLanguage
enISSN
1365-3083ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-3083.2008.02112.x
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