Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.

2.50
Hdl Handle:
http://hdl.handle.net/10033/30322
Title:
Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.
Authors:
Grenningloh, R; Darj, A; Bauer, H; zur Lage, S; Chakraborty, T; Jacobs, T; Weiss, S
Abstract:
Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.
Affiliation:
Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Citation:
Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. 2008, 67 (6):594-602 Scand. J. Immunol.
Journal:
Scandinavian journal of immunology
Issue Date:
Jun-2008
URI:
http://hdl.handle.net/10033/30322
DOI:
10.1111/j.1365-3083.2008.02112.x
PubMed ID:
18433404
Type:
Article
Language:
en
ISSN:
1365-3083
Appears in Collections:
publications of the research group molecular Immunology (MOLI)

Full metadata record

DC FieldValue Language
dc.contributor.authorGrenningloh, R-
dc.contributor.authorDarj, A-
dc.contributor.authorBauer, H-
dc.contributor.authorzur Lage, S-
dc.contributor.authorChakraborty, T-
dc.contributor.authorJacobs, T-
dc.contributor.authorWeiss, S-
dc.date.accessioned2008-06-23T13:21:39Z-
dc.date.available2008-06-23T13:21:39Z-
dc.date.issued2008-06-
dc.identifier.citationLiposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. 2008, 67 (6):594-602 Scand. J. Immunol.en
dc.identifier.issn1365-3083-
dc.identifier.pmid18433404-
dc.identifier.doi10.1111/j.1365-3083.2008.02112.x-
dc.identifier.urihttp://hdl.handle.net/10033/30322-
dc.description.abstractProtection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.en
dc.language.isoenen
dc.titleLiposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.en
dc.typeArticleen
dc.contributor.departmentMolecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalScandinavian journal of immunologyen

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