Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/305199
Title:
Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis.
Authors:
Kanjarawi, Reem; Dy, Michel; Bardel, Emilie; Sparwasser, Tim ( 0000-0001-5645-902X ) ; Dubois, Bertrand; Mecheri, Salah; Kaiserlian, Dominique
Abstract:
Anaphylaxis is a life-threatening outcome of immediate-type hypersensitivity to allergen, consecutive to mast cell degranulation by allergen-specific IgE. Regulatory T cells (Treg) can control allergic sensitization and mast cell degranulation, yet their clinical benefit on anaphylactic symptoms is poorly documented. Here we investigated whether Treg action during the effector arm of the allergic response alleviates anaphylaxis.
Affiliation:
CIRI, International Center for Infectiology Research, Mucosal immunity, Vaccination & Biotherapies Team, Université de Lyon, Lyon, France.
Citation:
Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. 2013, 8 (7):e69183 PLoS ONE
Journal:
PloS one
Issue Date:
2013
URI:
http://hdl.handle.net/10033/305199
DOI:
10.1371/journal.pone.0069183
PubMed ID:
23922690
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the TwinCore unit Infection immunology

Full metadata record

DC FieldValue Language
dc.contributor.authorKanjarawi, Reemen
dc.contributor.authorDy, Michelen
dc.contributor.authorBardel, Emilieen
dc.contributor.authorSparwasser, Timen
dc.contributor.authorDubois, Bertranden
dc.contributor.authorMecheri, Salahen
dc.contributor.authorKaiserlian, Dominiqueen
dc.date.accessioned2013-11-11T15:14:32Zen
dc.date.available2013-11-11T15:14:32Zen
dc.date.issued2013en
dc.identifier.citationRegulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. 2013, 8 (7):e69183 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid23922690en
dc.identifier.doi10.1371/journal.pone.0069183en
dc.identifier.urihttp://hdl.handle.net/10033/305199en
dc.description.abstractAnaphylaxis is a life-threatening outcome of immediate-type hypersensitivity to allergen, consecutive to mast cell degranulation by allergen-specific IgE. Regulatory T cells (Treg) can control allergic sensitization and mast cell degranulation, yet their clinical benefit on anaphylactic symptoms is poorly documented. Here we investigated whether Treg action during the effector arm of the allergic response alleviates anaphylaxis.en
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.titleRegulatory CD4+Foxp3+ T cells control the severity of anaphylaxis.en
dc.typeArticleen
dc.contributor.departmentCIRI, International Center for Infectiology Research, Mucosal immunity, Vaccination & Biotherapies Team, Université de Lyon, Lyon, France.en
dc.identifier.journalPloS oneen

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