Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia.

2.50
Hdl Handle:
http://hdl.handle.net/10033/311617
Title:
Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia.
Authors:
Karch, André ( 0000-0003-3014-8543 ) ; Manthey, Henrike; Ponto, Claudia; Hermann, Peter; Heinemann, Uta; Schmidt, Christian; Zerr, Inga
Abstract:
Since more than a decade ApoE is known to be a strong risk factor for Alzheimer's disease (AD); however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier (BBB). In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by albumin ratio (QAlb) in a large cohort of patients with different types of dementia.
Citation:
Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia. 2013, 8 (12):e84405 PLoS ONE
Journal:
PloS one
Issue Date:
2013
URI:
http://hdl.handle.net/10033/311617
DOI:
10.1371/journal.pone.0084405
PubMed ID:
24386372
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of the department of epidemiology (EPID)

Full metadata record

DC FieldValue Language
dc.contributor.authorKarch, Andréen
dc.contributor.authorManthey, Henrikeen
dc.contributor.authorPonto, Claudiaen
dc.contributor.authorHermann, Peteren
dc.contributor.authorHeinemann, Utaen
dc.contributor.authorSchmidt, Christianen
dc.contributor.authorZerr, Ingaen
dc.date.accessioned2014-01-21T13:24:20Z-
dc.date.available2014-01-21T13:24:20Z-
dc.date.issued2013-
dc.identifier.citationInvestigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia. 2013, 8 (12):e84405 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid24386372-
dc.identifier.doi10.1371/journal.pone.0084405-
dc.identifier.urihttp://hdl.handle.net/10033/311617-
dc.description.abstractSince more than a decade ApoE is known to be a strong risk factor for Alzheimer's disease (AD); however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier (BBB). In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by albumin ratio (QAlb) in a large cohort of patients with different types of dementia.en
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.titleInvestigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia.en
dc.typeArticleen
dc.identifier.journalPloS oneen

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