Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.

2.50
Hdl Handle:
http://hdl.handle.net/10033/322836
Title:
Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.
Authors:
Sudhakar, Padhmanand; Reck, Michael; Wang, Wei; He, Feng Q; Dobler, Irene W; Zeng, An-Ping ( 0000-0001-9768-7096 )
Abstract:
Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out.
Citation:
Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. 2014, 15:362 BMC Genomics
Journal:
BMC genomics
Issue Date:
2014
URI:
http://hdl.handle.net/10033/322836
DOI:
10.1186/1471-2164-15-362
PubMed ID:
24884510
Type:
Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
collections of the research group microbial communication (KOM)

Full metadata record

DC FieldValue Language
dc.contributor.authorSudhakar, Padhmananden
dc.contributor.authorReck, Michaelen
dc.contributor.authorWang, Weien
dc.contributor.authorHe, Feng Qen
dc.contributor.authorDobler, Irene Wen
dc.contributor.authorZeng, An-Pingen
dc.date.accessioned2014-07-11T14:15:35Zen
dc.date.available2014-07-11T14:15:35Zen
dc.date.issued2014en
dc.identifier.citationConstruction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. 2014, 15:362 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid24884510en
dc.identifier.doi10.1186/1471-2164-15-362en
dc.identifier.urihttp://hdl.handle.net/10033/322836en
dc.description.abstractCarolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out.en
dc.language.isoenen
dc.rightsArchived with thanks to BMC genomicsen
dc.titleConstruction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.en
dc.typeArticleen
dc.identifier.journalBMC genomicsen

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